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Hiperglisemik Glukoz Metabolizma Bozukluğu Olan Hastalarda Serum Malondialdehit, a-Tokoferol ve p-Karoten Düzeyleri

Serum MDA, a-Tocopherol and P-Carotene Levels in Patients Having Hyperglycemic Glucose Metabolism Disorders

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Abstract (2. Language): 
Objectives: Evaluation of serum MDA a-tocopherol and (3-carotene in patients having diabetes mellitus (DM), impaired glucose tolerance (IGT) and impaired fasting glucose (IFG). Materials and Methods: Ninety-nine patients, who were detected to have DM, IGT or IFG at their admission to Zonguldak Karaelmas University Hospital, Family Medicine or Internal Medicine outpatient clinics, and 37 healthy controls were included in the study. MDA a-tocopherol and b-carotene levels were studied in the serum samples of all patients and controls. Results: While MDA level in DM group was significantly higher than the IGT, IFG and control groups, a-tocopherol level in DM group was lower than the control group and (3-carotene level was lower than IGT, IFG and control groups. While MDA level in IGT group was significantly higher than the IFG and control groups, a-tocopherol level in IGT group was lower than the control group and (3-carotene level was lower than IFG and control groups. There was no significant difference of any of the three parameters between IFG and control groups Conclusion: While lipid peroxidation increases, a-tocopherol and (3-carotene levels decrease in the diseases with hyperglycemia, except IFG ©2005, Fırat Üniversitesi, Tıp Fakültesi
Abstract (Original Language): 
Amaç: Diabetes mellitus (DM), bozulmuş glukoz toleransı (BGT) ve bozulmuş açlık glukozu (BAG) olan hastalarda serum MDA D-tokoferol ve • -karoten düzeylerinin değerlendirilmesi. Gereç ve Yöntem: Zonguldak Karaelmas Üniversitesi Hastanesi Aile hekimliği ve Dahiliye polikliniklerine başvuran ve yapılan tetkiklerle DM, BGT ve BAG olduğuna karar verilen toplam 99 hasta ve 37 sağlıklı kontrol çalışmaya dahil edildi. Hasta ve kontrol gruplarına ait serum örneklerinde MDA a-tokoferol ve b-karoten çalışıldı. Bulgular: DM grubunun MDA düzeyi BGT, BAG ve kontrol gruplarından anlamlı derecede yüksek bulunurken, a-tokoferol düzeyi kontrol grubundan, (3-karoten düzeyi ise BGT, BAG ve kontrol gruplarından düşük bulundu. BGT grubunun MDA düzeyi BAG ve kontrol gruplarından anlamlı derecede yüksek bulunurken, a-tokoferol düzeyi kontrol grubundan, (3-karoten düzeyi ise BAG ve kontrol gruplarından düşük bulundu. BAG grubu ile kontrol grubu arasında her üç parametre açısından da anlamlı fark yoktu. Sonuç: BAG hariç, diğer hiperglisemi ile seyreden hastalıklarda lipid peroksidasyonu artarken, a-tokoferol ve (3-karoten seviyeleri düşmektedir. ©2005, Fırat Üniversitesi, Tıp Fakültesi

REFERENCES

References: 

1. Cheeseman KH, Slater TF. An introduction to free radical biochemistry. Br Med Bull 1993; 49: 81-493.
2. Nakazawa T, Nagatsuka S. Radiation-induced lipid peroxidation and membrane permeability in liposomes. Int J Radiat Biol Relat Stud Phys Chem Med 1980; 38: 537-544.
3. Church DF, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985; 64: 111-126.
4. Halliwell B, Gutteridge JM. Free radicals, lipid peroxidation, and cell damage. Lancet 1984; 2: 1095.
5. Mercuri F, Quagliaro L, Ceriello A Oxidative stress evaluation in diabetes. Diabetes Technol Ther 2000; 2: 589-600.
6. Gey KF. Prospects for the prevention of free radical disease, regarding cancer and cardiovascular disease. Br Med Bull 1993; 49: 679-699.
7. Burlakova EB, Krashakov SA, Khrapova NG. The role of tocopherol in biomembrane lipid peroxidation. Membr Cell Biol 1998; 12: 173-211.
8. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 1990; 186: 421-430.
9. Hashim SA, Schuttringer GR. Rapid determination of tocopherol in marco- and microquantities of plasma. Results obtained in various nutrition and metabolic studies. Am J Clin Nutr 1966; 19: 137-145.
10. Cals MJ, Succari M, Meneguzzer C. Markers oxidative stress in fit, health-conscious elderly people living in the paris area. Nutrition 1997; 13:319-326.
11. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40: 405- 412.
12. Kowluru RA, Odenbach S. Role of interleukin-lbeta in the pathogenesis of diabetic retinopathy. Br J Ophthalmol 2004; 88: 1343-1347.
13. Dulak J, Tornala K, Loboda A, Jozkowicz A Nitric oxide-dependent synthesis of vascular endothelial growth factor is impaired by high glucose. Life Sci 2004; 75: 2573-2586.
14. Li H, Gutterman DD, Rusch NJ, Bubolz A, Liu Y. Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose. Diabetes 2004; 53: 2436¬2442.
15. Keynan S, Khamaisi M, Dahan R, Barnes K, Jackson CD, Turner AJ, Raz I. Increased expression of endothelin-converting enzyme-lc isoform in response to high glucose levels in endothelial cells. J Vase Res 2004; 41: 131-140.
16. Weidig P, McMaster D, Bayraktutan U. High glucose mediates pro-oxidant and antioxidant enzyme activities in coronary endothelial cells. Diabetes Obes Metab 2004; 6: 432-441.
17. Yang X, Borg LAH and Eriksson UJ. Altered metabolism and superoxide generation in neural tissue of rat embryos exposed to high glucose. Am J Physiol 1997; E173-E180.
18. Zanetti M, Zwacka RM, Engelhardt JF, Katusic ZS and O Brien T. Superoxide anions and endothelial cell proliferation in normoglycemia and hyperglycemia. Arterioscler Thromb Vase Biol 2001; 21: 195-200.
19. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I and Brownlee M. Normalizing mitochondrial superoxide
production blocks three pathways of hyperglycaemic damage. Nature 2000; 404: 787-790.
20. Wautier MP, Chappey O, Corda S, Stern DM, Schmidt AM and Wautier JL. Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. Am J Physiol 2001; 280:685-694.
21. Kinalski, M, Sledziewski A, Telejko B, Zarzycki W, Kinalska I. Lipid peroxidation and scavenging enzyme activity in streptozotocin-induced diabetes. Acta Diabetol 2000; 37: 179¬183.
22. Costagliola C, Lulona G, Menziona A, Nesti A, Simonelli F, Rinoldi E. Systematic human disease as oxidative risk factor in cataragenesis. Ophtalmic Res 1988; 20: 308-316.
23. Ceriolle A, Giuptiano D, Quatroza A, Donzello C, Dipalo G, Lefebuer PJ. Vitamin E reduction of protein glycosylation in diabetics: new prospect for prevention of diabetic complications. Diabetic Care 1991; 14: 68-72.
24. Gopaul NK, Manraj MD, Hebe A, Yan SLK, Johnston A, Carrier MJ, Anggard EE. Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism. Diabetologia 2001; 44: 706-712.
25. Stahl W, Sies H. Antioxidant defense: vitamins E and C and carotenoids. Diabetes 1997; 46: 14-18.
26. Ford ES, Mokdad AH, Ajani UA, Liu S. Associations between concentrations of alphD- and gammD-tocopherol and concentrations of glucose, glycosylated haemoglobin, insulin and C-peptide among US adults. Br JNutr 2005; 93: 249-255.
27. Sundaram RK, Bhaskar A, Vijayalingam S, Viswanathan M, Mohan R, Shanmugasundaram KR. Antioxidant status and lipid peroxidation in type II diabetes mellitus with and without complications. Clin Sci (Lond) 1996; 90: 255-260.
28. Facchini FS, Humphreys MH, DoNascimento CA, Abbasi F, Reaven GM. Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols. Am J Clin Nutr 2000; 72: 776-779.
29. Öhrvall M, Tengblad S, Vessby B. Lower tocopherol serum levels in subjects with abdominal adiposity. J Intern Med 1993; 234: 53-60.
30. Salonen JT, Nyyssönen K, Tuomainen TP, et al. Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. BMJ 1995; 311: 1124-1127.
31. Ylönen K, Alfthan G, Groop L, Saloranta C, Aro A, Virtanen SM. Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study. Am J Clin Nutr 2003; 77: 1434-1441.
32. Decsi T, Molnâr D, Koletzko B. Lipid corrected plasma a-tocopherol values are inversely related to fasting insulinaemia in obese children. Int J Obes Relat Metab Disord 1996; 20: 970¬972.
33. Clinton SK. Lycopene: chemistry, biology, and implications forhuman health and disease. Nutr Rev 1998; 56: 35-51.
34. Azzi A, Breyer I, Feher M, et al. Specific cellular responses to a-tocopherol. JNutr 2000; 130: 1649-1652.
35. Traber MG, Packer L. Vitamin E: beyond antioxidant function. Am J Clin Nutr 1995; 62: 1501-1509.

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