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Uzun Süreli Ranitidin Tedavisi alan Olguda Nondepolarizan Bloker Ajanlara Karşı Rezistans Gelişimi (Olgu Sunumu)

Resistance to Nondepolarizing Blocking Agents in a Patient Prolonged Treatment with Ranitidine

Journal Name:

  • Fırat Tıp Dergisi

Publication Year:

  • 2007

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
We report a case of a 65-year-old man with a history of duodenal ulcer that treated preoperatively with ranitidine and underwent surgical exploration for upper gastrointestinal hemorrhage under emergency conditions. Under general anaesthesia, he showed resistance to two nondepolarizing neuromuscular blocking drugs. No obvious cause for the resistance was demonstrated except for the possibility of an interaction between ranitidine with vecuronium and mivacurium. ©2007, Fırat Üniversitesi, Tıp Fakültesi
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Abstract (Original Language): 
Biz bu yazıda, 65 yaşında, duodenal ülser nedeniyle uzun süredir ranitidine tedavisi gören ve üst gastrointestinal sistem kanaması nedeniyle opere olan erkek olguyu sunduk. Genel anestezi altında opere olan olguda nondepolarizan kas gevseticilerden vekuronium ve mivakuriuma karşı rezistans gelişti. Rezistans oluşturacak mekanizmalar arasında vekuronium ve mivakuriumun ranitidin ile etkileşmesi en büyük olasılıktır. ©2007, Fırat Üniversitesi, Tıp Fakültesi
FULL TEXT (PDF): 
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  • 2
146-148
  • Turkish

REFERENCES

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Although no clinical findings, hypothyroidism could be the reason for the resistance. In addition to this, increased level of endogenous testosterone and steroidal-core structure of vecuronium may explain the increased tolerance to vecuronium in this patient. Regarding as far as plasma cholinesterase is concerned, ıncreased plasma cholinesterase activity might be the clinical discovery. In the patient, all laboratory investigations were in normal limits. That is to say, supporting neuromuscular resistance of patient was no laboratory result.
We want to stress that some drugs may cause vital advers effects being used in over time
In conclusion, we would like to point out that anesthesiologists should be aware that ranitidine can cause resistance to vecuronium and mivacurium.
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