You are here

Endometriyozisde güncel yaklaşım

Current approach to endometriosis

Journal Name:

Publication Year:

Author Name
Abstract (2. Language): 
Endometriosis is defined as the presence of endometrial tissue outside the uterus. It is mostly localized to the pelvic viscera and the peritoneum in women during the reproductive period. Endometriosis is observed in a wide spectrum of clinical presentations such as minimal lesions, adhesions involving bladder, ureter, bowel, and massive endometriomas distorting the tuboovarian anatomy. Pelvic pain and infertility are frequently observed in patients with endometriosis. The present review summarizes the pathogenesis and diagnosis of endometriosis, pelvic pain and infertility related to endometriosis and their current therapeutic approach.
Abstract (Original Language): 
Endometriyozis, endometriyal dokunun uterus dışında yerleşimi olarak tanımlanır. En sık pelvisteki organlara ve peritona lokalize olmakta ve üreme dönemindeki kadınları etkilemektedir. Ufak lezyonlardan, mesane, üreter ve barsakları içeren adezyonlara, tuba ve overlerin anatomisini bozan büyük çaplı endometriyomalara kadar değişik klinik yelpazede izlenmektedir. Endometriyozis hastalarında sıklıkla pelvik ağrı ve infertilite gözlenmektedir. Bu derlemede endometriyozisin patogenezi, tanı yöntemleri, endometriyozise bağlı ağrı ve infertilite ile güncel tedavi yaklaşımları özetlenmektedir.
318-323

REFERENCES

References: 

1. Anaf V, Simon P, Fayt I, Noel J Smooth
muscles are frequent components of
endometriotic lesions. Hum Reprod 2000;
15: 767-771.
2. Nisolle M, Donnez J. Peritoneal
endometriosis, ovarian endometriosis, and
adenomyotic nodules of the rectovaginal
septum are three different entities. Fertil
Steril 1997; 68: 585-596.
3. Brosens IA, Brosens JJ. Redefining
endometriosis: is deep endometriosis a progressive disease? Hum Reprod 2000; 15: 1-
3.
4. Missmer SA, Cramer DW. The epidemiology of endometriosis. Obstet Gynecol Clin
North Am 2003; 30: 1-19.
5. Nothnick WB. Treating endometriosis as
an autoimmune disease. Fertil Steril 2001;
76: 223-231.
6. Matarese G, De Placido G, Nikas Y, Alviggi
C. Pathogenesis of endometriosis: natural
immunity dysfunction or autoimmune disease? Trends Mol Med 2003; 9: 223-228.
7. Barrier BF, Bates GW, Leland MM, Leach
DA, Robinson RD, Propst AM. Efficacy of
anti-tumor necrosis factor therapy in the
treatment of spontaneous endometriosis in
baboons. Fertil Steril 2004; 81: 775-779.
8. Beliard A, Noel A, Foidart JM. Reduction
of apoptosis and proliferation in
endometriosis. Fertil Steril 2004; 82: 80-85.
9. Gogusev J, Bouquet de Joliniere J, Telvi L,
Doussau M, Stojkoski A, Levardon M.
Cellular and genetic constitution of human
endometriosis tissues. J Soc Gynecol
Investig 2000; 7: 79-87.
10. Eyster KM, Boles AL, Brannian JD,
Hansen KA. DNA microarray analysis of
gene expression markers of endometriosis.
Fertil Steril 2002; 77: 38-42.
11. Takahashi K, Okada M, Okada S, Kitao M,
Imaoka I, Sugimura K. Studies on the
detection of small endometrial implants by
magnetic resonance imaging using a fat saturation technique. Gynecol Obstet Invest
1996; 41: 203-206.
12. Timmerman D, Bourne TH, Tailor A, et
al. A comparison of methods for preoperative discrimination between malignant and
benign adnexal masses: the development of
a new logistic regression model. Am J
Obstet Gynecol 1999; 181: 57-65.
13. Aleem F, Pennisi J, Zeitoun K, Predanic M.
The role of color Doppler in diagnosis of
endometriomas. Ultrasound Obstet
Gynecol 1995; 5: 51-54.
14. Guerriero S, Ajossa S, Mais V, Risalvato A,
Lai MP, Melis GB. The diagnosis of
endometriomas using colour Doppler
energy imaging. Hum Reprod 1998; 13:
1691-1695.
15. Koninckx PR, Riittinen L, Seppala M,
Cornillie FJ. CA-125 and placental protein
14 concentrations in plasma and peritoneal
fluid of women with deeply infiltrating
pelvic endometriosis. Fertil Steril 1992; 57:
523-530.
16. Chapron C, Liaras E, Fayet P, et al.
Magnetic resonance imaging and
endometriosis: deeply infiltrating endometriosis does not originate from the rectovaginal septum. Gynecol Obstet Invest
2002; 53: 204-208.
17. Chapron C, Dumontier I, Dousset B, et al.
Results and role of rectal endoscopic ultrasonography for patients with deep pelvic
endometriosis. Hum Reprod 1998; 13:
2266-2270.
18. Fedele L, Bianchi S, Portuese A, Borruto F,
Dorta M. Transrectal ultrasonography in
the assessment of rectovaginal endometriosis. Obstet Gynecol 1998; 91: 444-448.
19. Brosens J, Timmerman D, StarzinskiPowitz A, Brosens I. Noninvasive diagnosis
of endometriosis: the role of imaging and
markers. Obstet Gynecol Clin North Am
2003; 30: 95-114.
20. Donnez J, Brosens I. Definition of ureteral
endometriosis? Fertil Steril 1997; 68: 178-
180.
21. Deprest J, Marchal G, Brosens I. Obstructive uropathy secondary to endometriosis.
N Engl J Med 1997; 337: 1174-1175.
22. Kitawaki J, Noguchi T, Amatsu T, et al.
Expression of aromatase cytochrome P450
protein and messenger ribonucleic acid in
human endometriotic and adenomyotic tissues but not in normal endometrium. Biol
Reprod 1997; 57: 514-519.
23. Kitawaki J, Kusuki I, Koshiba H,
Tsukamoto K, Fushiki S, Honjo H.
Detection of aromatase cytochrome P-450
in endometrial biopsy specimens as a diagnostic test for endometriosis. Fertil Steril
1999; 72: 1100-1106.
24. Dheenadayalu K, Mak I, Gordts S, et al.
Aromatase P450 messenger RNA expression in eutopic endometrium is not a specific marker for pelvic endometriosis. Fertil
Steril 2002; 78: 825-829.
25. Abrao MS, Podgaec S, Pinotti JA, de
Oliveira RM. Tumor markers in
endometriosis. Int J Gynaecol Obstet 1999;
66: 19-22.
26. Mol BW, Bayram N, Lijmer JG, et al. The
performance of CA-125 measurement in
the detection of endometriosis: a metaanalysis. Fertil Steril 1998; 70: 1101-1108.
27. Pittaway DE, Rondinone D, Miller KA,
Barnes K. Clinical evaluation of CA-125
concentrations as a prognostic factor for
pregnancy in infertile women with surgically treated endometriosis. Fertil Steril
1995; 64: 321-324.
28. Bedaiwy MA, Falcone T, Sharma RK, et al.
Prediction of endometriosis with serum
and peritoneal fluid markers: a prospective
controlled trial. Hum Reprod 2002; 17:
426-431.
29. Bedaiwy MA, Falcone T. Laboratory testing
for endometriosis. Clin Chim Acta 2004;
340: 41-56.
30. Mahutte NG, Arici A. Medical management of endometriosis-associated pain.
Obstet Gynecol Clin North Am 2003; 30:
133-150.
31. Vercellini P, De Giorgi O, Mosconi P,
Stellato G, Vicentini S, Crosignani PG.
Cyproterone acetate versus a continuous
monophasic oral contraceptive in the treatment of recurrent pelvic pain after conservative surgery for symptomatic endometriosis. Fertil Steril 2002; 77: 52-61.
32. Dawood MY. Dysmenorrhea. J Reprod
Med 1985; 30: 154-167.
33. Weaver AL. Rofecoxib: clinical pharmacology and clinical experience. Clin Ther
2001; 23: 1323-1338.
34. Vercellini P, Aimi G, Panazza S, De Giorgi
O, Pesole A, Crosignani PG. A levonorgestrel-releasing intrauterine system
for the treatment of dysmenorrhea associated with endometriosis: a pilot study. Fertil
Steril 1999; 72: 505-508.
35. Vercellini P, Cortesi I, Crosignani PG.
Progestins for symptomatic endometriosis:
a critical analysis of the evidence. Fertil
Steril 1997; 68: 393-401.
36. Hidalgo M, Bahamondes L, Perrotti M,
Diaz J, Dantas-Monteiro C, Petta C.
Bleeding patterns and clinical performance
of the levonorgestrel-releasing intrauterine
system (Mirena) up to two years.
Contraception 2002; 65: 129-132.
37. Fedele L, Bianchi S, Zanconato G, Portuese
A, Raffaelli R. Use of a levonorgestrelreleasing intrauterine device in the treatment of rectovaginal endometriosis. Fertil
Steril 2001; 75: 485-488.
38. Bergqvist A, Bergh T, Hogstrom L,
Mattsson S, Nordenskjold F, Rasmussen
C. Effects of triptorelin versus placebo on
the symptoms of endometriosis. Fertil
Steril 1998; 69: 702-708.
39. Fedele L, Bianchi S, Bocciolone L, Di Nola
G, Franchi D. Buserelin acetate in the treatment of pelvic pain associated with minimal and mild endometriosis: a controlled
study. Fertil Steril 1993; 59: 516-521.
40. Surrey ES, Hornstein MD. Prolonged
GnRH agonist and add-back therapy for
symptomatic endometriosis: long-term follow-up. Obstet Gynecol 2002; 99: 709-719.
41. Blumenfeld Z. Hormonal suppressive therapy for endometriosis may not improve
patient health. Fertil Steril 2004; 81: 487-
492.
42. Navarro J, Garrido N, Remohi J, Pellicer A.Cilt 47 · Sayý 4 · Gülhane TD Endometriyozis · 323
How does endometriosis affect infertility?
Obstet Gynecol Clin North Am 2003; 30:
181-192.
43. Garrido N, Navarro J, Garcia-Velasco J,
Remoh J, Pellice A, Simon C. The
endometrium versus embryonic quality in
endometriosis-related infertility. Hum
Reprod Update 2002; 8: 95-103.
44. Adamson GD, Pasta DJ. Surgical treatment
of endometriosis-associated infertility:
meta-analysis compared with survival
analysis. Am J Obstet Gynecol 1994; 171:
1488-1504.
45. Guzick DS, Bross D. Convenient numerical procedures for estimating cumulative
pregnancy curves. Fertil Steril 1992; 57: 85-
91.
46. Zikopoulos K, Kolibianakis EM, Devroey
P. Ovarian stimulation for in vitro fertilization in patients with endometriosis. Acta
Obstet Gynecol Scand 2004; 83: 651-655.
47. Wong BC, Gillman NC, Oehninger S,
Gibbons WE, Stadtmauer LA. Results of in
vitro fertilization in patients with
endometriomas: is surgical removal beneficial? Am J Obstet Gynecol 2004; 191: 597-
606.
48. Exacoustos C, Zupi E, Amadio A, et al.
Laparoscopic removal of endometriomas:
sonographic evaluation of residual functioning ovarian tissue. Am J Obstet
Gynecol 2004; 191: 68-72.
49. Pabuccu R, Onalan G, Goktolga U, Kucuk
T, Orhon E, Ceyhan T. Aspiration of ovarian endometriomas before intracytoplasmic
sperm injection. Fertil Steril 2004; 82: 705-
711.
50. Garcia-Velasco JA, Mahutte NG, Corona J,
et al. Removal of endometriomas before in
vitro fertilization does not improve fertility
outcomes: a matched, case-control study.
Fertil Steril 2004; 81: 1194-1197.

Thank you for copying data from http://www.arastirmax.com