You are here

Diyabetes mellituslu olgularda santral kornea kalınlığı ve retina sinir lifi kalınlığı

Central corneal and retinal nerve fiber layer thickness in patients with diabetes mellitus

Journal Name:

Publication Year:

Abstract (2. Language): 
It has been shown that diabetes mellitus and systemic hypertension each are the risk factors for high intraocular pressure. The aim of this study was to assess the correlation between glaucoma, and central corneal thickness and retinal nerve fiber layer thickness in patients with diabetes mellitus. Patients diagnosed to have diabetes mellitus type 2 (fasting glucose level 126 ml/dL) without systemic hypertension and glaucoma were enrolled in the study. The patients were divided into three groups according to their diabetes duration (0-5, 6-10 and 11- 15 years). Central corneal thickness measurements were made with Pacline Opticone Ultrasonic Pacimetry. Retinal nerve fiber layer thickness measurements were made with NFA II, GDx VCC. Data of the patients were compared with the findings of a control group consisting of healthy subjects. There were no significant differences between the control and other groups with respect to age and gender. Central corneal thickness was 544.17±37.95 in the control group, 543.89±33.37 in Group 1, 548.55±37.48 in Group 2, 552.11±32.53 in Group 3, and there were no significant differences between the control and other groups (p>0.05). There were also no significant differences between the control and other groups with respect to parameters such as TSNIT, SA, IA and NFI in the measurement of retinal nerve fiber layer thickness. There were not statistically significant differences between the diabetic patients and the control group on the basis of measurements of central corneal thickness and retinal nerve fiber layer thickness.
Abstract (Original Language): 
Diyabetes mellitus ve sistemik hipertansiyonun, yükselmiş göz içi basıncı için birer risk faktörü olduğu gösterilmiştir. Bu çalışmada diyabetes mellitusu olan hastalarda, santral kornea kalınlığı ve retina sinir lifi tabakası kalınlığı ölçülerek, glokom ile olan ilişkisi araştırılmıştır. Tip II diyabetes mellitus tanısı alan (açlık kan şekeri 126 mg/dL ve üzeri), sistemik hipertansiyonu ve glokomu olmayan olgular çalışmaya alındı. Diyabetli hastalar, diyabet süresi 0-5 yıl, 6-10 yıl, 11-15 yıl olmak üzere 3 gruba ayrıldı. Olguların santral kornea kalınlıkları Pacline Optikon Ultrasonik pakimetre cihazı ile ölçüldü. Retina sinir lifi kalınlığı ölçümü ise NFA II, GDx VCC cihazı ile yapıldı. Çalışmaya alınan olguların bulguları, sağlıklı bireylerden oluşan kontrol grubunun bulgularıyla karşılaştırıldı. Kontrol grubu ile diğer gruplar arasında yaş ve cins yönünden istatistiksel olarak anlamlı farklılık yoktu. Santral kornea kalınlığı kontrol grubunda 544.17±37.95, Grup I'de 543.89±33.37, Grup II'de 548.55±37.48, Grup III'de 552.11±32.53 idi ve kontrol grubu ile diğer gruplar arasında istatistiksel olarak anlamlı farklılık bulunamadı (p>0.05). Retina sinir lifi tabakası kalınlığı ölçümü açısından bakıldığında ise, TSNIT, SA, IA, NFI gibi parametreler incelendiğinde aynı şekilde kontrol grubu ile diğer gruplar arasında istatistiksel olarak anlamlı farklılık bulunamadı. Diyabetik hastalardaki santral kornea kalınlığı ve retina sinir lifi tabakası kalınlığı kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı bir farklılık göstermiyordu.
91-95

REFERENCES

References: 

1. Leung CK, Chan W, Chong KK,
et al. Comparative study of retinal
nerve fiber layer measurement by
Stratus OCT and GDx VCC, I:
correlation analysis in glaucoma.
Invest Ophthalmol Vis Sci 2005;
46: 3214-3220.
2. Klein BE, Klein R, Jensen SC.
Open angle glaucoma and older
onset diabetes: The Beaver Dam
Eye Study. Ophthalmology 1994;
101: 1173-1177.
3. Mitchell P, Smith W, Chey T, et
al. Open angle glaucoma and diabetes: The Bluemauntains Eye
Study, Australia. Ophthalmology
1977; 104: 712-718.
4. Lopes JM, Russ H, Costa VP.
Retinal nerve fiber layer loss in
patients with type 1 diabetes mellitus without retinopathy. Br J
Ophthalmol 2002; 86: 725-728.
5. Chiara H, Matsuoka T, Ogura Y,
et al. Retinal nerve fiber layer
defects as an early manifestation
of diabetic retinopathy. Ophthalmology 1993; 100: 1147-1151.
6. Varkonyi TT, Peto T, Degi R, et
al. Impairment of visual evoked
potentials: an early central manifestation of diabetik neuropathy?
Diabetes Care 2002; 25: 1661-
1662.
7. Greenstein VC, Shapirove A,
Zaidi Q, et al. Psychophysical evidence for post-reseptoral sensitivity loss in diabetes. Invest Ophthalmol Vis Sci 1992; 33: 2781-
2790.
8. Amemiya T. Dark adaptation in
diabetics. Ophthalmologica 1977;
174: 322-326.
9. Chiara E, Zhang S. Analysis of
diabetic optic neuropathy with a
topographic laser scanning system. Nippon Ganka Gakkai Zassi
1998; 102: 431-435.
10. Sommer A, Katz J, Quigley HA,
et al. Clinically detectable nerve
fiber atrophy precedes the onset
of glaucomatous field loss. Arch
Ophthalmol 1991; 109: 77-83.
11. Gardner TW, Antonetti DA,
Barber AJ, et al. Diabetic retinopathy: more than meets the eye.
Surv Ophthalmol 2002; 47: 253-
262.
12. Conceiçao LL, Bernardes RC,
Abreu RF, et al. One-year followup of blood-retinal barrier and
retinal thickness alterations in
patients with type 2 diabetes mellitus and mild nonproliferative
retinopathy. Arch Ophthalmol
2001; 119: 1469-1474.
13. Conceiçao LL, Bernardes RC,
Figueira JP, et al. Three-year follow-up of blood-retinal barrier
and retinal thickness alterations in
patients with type 2 diabetes mellitus and mild nonproliferative
retinopathy. Arch Ophthalmol
2004; 122: 211-217.
14. Ozdek S, Lonneville YH, Önol
M, Yekin I, Hasanreisoðlu B.
Assessment of nevre fiber layer in
diabetic patients with scanning
laser polarimetry. Eye 2002; 16:
761-765.
15. Takahashi H, Goto T, Shojý T, et
al. Diabetes associated retinal
nevre fiber damage evaluated with
scanning laser polarimetry. Am J
Ophthalmol 2006; 142: 88-94.
16. Keoleian GM, Pach JM, David
OH, et al. Structural and functional studies of the corneal
endothelium in diabetes mellitus.
Am J Ophthalmol 1992; 113: 64-
70.
17. Schultz RO, Matsuda M, Yee R,
et al. Corneal endothelial changes
in type 1 and 2 diabetes mellitus.
Am J Ophthalmol 1984; 98: 401-
410.
18. Bayraktar MZ, Yýldýrým E,
Karagül S, et al. Diyabetik retinopatili olgularda endotel deðiþikliklerinin speküler mikroskopi ile
deðerlendirilmesi. TODXX. Ulusal Kongresi, 1989, Bursa. Kongre
Özet Kitabý, 522-526.
19. Ermiþ SS, Ermiþ F, Erþanlý D ve
ark. Ýnsüline baðýmlý diyabetes
mellitusta santral kornea kalýnlýðý.Cilt 49 · Sayý 2 · Gülhane TD Diyabetes mellitus, kornea ve retina kalýnlýðý · 95
MN Oftalmoloji 2001; 8: 369-
371.
20. Busted N, Olsen T, Schimitz O.
Clinical observation on the corneal thickness and the corneal endothelium in diabetes mellitus. Br
J Ophthalmol 1981; 65: 687-690.
21. Larsson LT, Bourne WM, Pach
JM, et al. Structure and function
of the corneal endothelium in diabetes mellitus type 1 and type 2.
Arch Ophthalmol 1996; 114: 9-
14.
22. Ravalico G, Tognetto D, Palomba
M, et al. Corneal endothelial
function in diabetes: a florometric
study. Ophthalmologica 1994;
208: 179-184.
23. Lass J, Spurney RV, Dutt RM, et
al. A morphologic and fluorophotometric analysis of the corneal
endothelium in type 1 diabetes
mellitus and cystic fibrosis. Am J
Ophthalmol 1985; 100: 783-788.

Thank you for copying data from http://www.arastirmax.com