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Lokal antimikrobiyal ajanların palatinal bölgeden alınan greft alanındaki doku defektinin iyileşmesi üzerine etkilerinin histomorfometrik yöntemle incelenmesi

The histomorphometrical evaluation of the effects of local antimicrobial agents in the healing of the tissue defect in the graft area obtained from the palatinal region

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2009

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Supportive use of chemotherapeutic agents after periodontal surgery contributes to wound healing and improves the clinical results decreasing the bacterial plaque accumulation, and postoperative pain and edema. In this study it was aimed to evaluate the macroscopic and histomorphometric effects of various antimicrobial agents administered topically on the experimentally excised wounds which were created on the palatine mucosa of rats in comparison to a control group. In the study, 84 Wistar rats were included, and a biopsy instrument that had a diameter of 4 mm was used to create a mucosal wound centrally on the palatine. On the experimentally excised defect sites chlorhexidine digluconate (CHX) 1% gel (Corsodyl®), octenidine (Octenisept®), polyhexanide solution (Prontoral®), hyaluronic acid 0.8% gel (Gengigel®) and isotonic saline solution in the control group each was used for one minute on every day. Defect diameters were detected on the 3rd, 7th, 14th and 21st days of histomorphometrically created wounds of sacrified rats. The mean distance between defect margins was significantly reduced in both the experiment and control groups in time. The most statistically significant reduction in defect diameters was achieved in the polyhexanide solution (Prontoral®) group (p<0.001). Tested oral agents showed no negative effects on wound healing when administered on the excisional wound site, and a best wound healing was achieved with polyhexanide solution. In conclusion topical applications of antimicrobial agents do not disrupt the healing process in the donor area, and they can be used to contribute to the healing of the surgical site.
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Abstract (Original Language): 
Periodontal cerrahi sonrasında yardımcı kemoterapötik ajan kullanımının bakteriyel plak birikimini, postoperatif ağrı ve ödemi azaltarak, yara iyileşmesine katkıda bulunduğu ve klinik sonuçları iyileştirdiği gösterilmiştir. Bu çalışmada topikal olarak uygulanan antimikrobiyal ajanların, ratlarda deneysel olarak oluşturulan palatinal eksizyonel yara bölgesine etkilerinin kontrol grubuyla karşılaştırmalı, makroskobik ve histomorfometrik olarak incelenmesi amaçlandı. Çalışma 84 erkek Wistar ratın damaklarının merkezinde punch biyopsi aletiyle oluşturulan 4 mm çapında eksizyonel yara ile gerçekleştirildi. Deneysel eksizyonel defektlerde klorheksidin diglukonat (CHX) %1 jel (Corsodyl®), oktenidin (Octenisept®), poliheksanid solüsyon (Prontoral ®), hyaluronik asid %0.8 jel (Gengigel®) ve kontrol grubu olarak da serum fizyolojik her gün 1 dakika olarak uygulandı. Defekt çapları histomorfometrik olarak yara oluşturulduktan sonraki 3., 7., 14. ve 21. günlerde sakrifiye edilen gruplarda tespit edildi. Deney ve kontrol gruplarında defekt kenarları arasındaki ortalama uzaklık zamanla anlamlı olarak azaldı. Defekt çaplarındaki en bü- yük azalma istatistiksel olarak anlamlı bir şekilde poliheksanid solüsyon (Prontoral®) kullanılan grupta görüldü (p<0.001). Çalışmada test edilen oral ajanların eksizyonel bir yara üzerine uygulandıklarında, yara iyileşmesi üzerine herhangi bir negatif etkiye sahip olmadıkları, bunun yanında poliheksanid solüsyon ile en iyi yara iyileşmesi sonucuna ulaşıldığı görüldü. Sonuç olarak antimikrobiyal ajanların topikal uygulamalarının donör bölgedeki iyileşme sürecini bozmadığı ve cerrahi bölgenin iyileşmesine katkıda bulunmak için kullanılabileceği düşünülmektedir.
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PDF icon arastirmax-lokal-antimikrobiyal-ajanlarin-palatinal-bolgeden-alinan-greft-alanindaki-doku-defektinin-iyilesmesi-uzerine-etkilerinin-histomorfometrik-yontemle-incelenmesi.pdf
  • 1
27-33
  • Turkish

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