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Yetişkin blastemal Wilms tümörüne benzerlik gösteren renal primer primitif nöroektodermal tümörün immünohistokimyasal özellikleri: olgu sunumu

The immunohistochemical features of the renal primary primitive neuroectodermal tumor mimicking adult blastemal Wilms tumor: a case report

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Abstract (2. Language): 
Primary primitive neuroectodermal tumor of the kidney is a rare and aggressive tumor. Its distinction from other primary renal tumors is clinically important due to different therapeutic management. A 44-year-old man was admitted to the hospital with left flank pain and hematuria. In computerized tomography, a mass in left kidney was detected and nephrectomy was performed. Microscopically the tumor was composed of small round cells. Immunohistochemically, diffuse strong positivity for CD 99 (MIC2) and NSE, and focal positivity for Wilms tumor 1 were determined in the tumor cells. In this report, a rare renal primary primitive neuroectodermal tumor showing both CD99 and Wilms tumor 1 expression is presented
Abstract (Original Language): 
Böbreğin primer primitif nöroektodermal tümörü seyrek görülen agresif bir tümördür. Farklı tedavi yaklaşımları nedeniyle, klinik olarak bu tümörün diğer primer renal tümörlerden ayırımı önemlidir. Kırk dört yaşında erkek hasta sol yan ağrısı ve hematüri şikayetleri ile hastaneye başvurdu. Bilgisayarlı tomografide sol böbrekte kitle saptandı ve nefrektomi uygulandı. Mikroskopik olarak, tümör küçük yuvarlak hücrelerden oluşmaktaydı. İmmünohistokimyasal olarak, tümör hücrelerinde yaygın ve kuvvetli CD 99 (MIC2) ve NSE, fokal Wilms tümör 1 pozitifliği saptandı. Bu yazıda CD 99 ve Wilms tümör 1 ekspresyonu gösteren ve seyrek görülen renal primer primitif nöroektodermal tümör olgusu sunulmuştur.
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REFERENCES

References: 

References
1. Dehner LP. Primitive neuroectodermal tumors (Ewing
sarcoma). In: Eble JN, Sauter G, Epstein JI, Sesterhenn
IA (eds). Pathology and Genetics of Tumours of the
Urinary System and Male Genital Organs. WHO
Classification of Tumours, IARCC Press, Lyon, France,
2004: 833-884.
2. Gonlusen G, Ergin M, Paydas Sİ, Bolat FA. Primitive
neuroectodermal tumor of the kidney: a rare entity. Int
Urol Nephrol 2001; 33: 449-451.
3. Sivaramakrishna B, Mundada OP, Aron M,
Vijayaraghavan M. Primary primitive neuroectodermal
tumor (PNET) of the kidney with venous thrombus. Int
Urol Nephrol 2003; 35: 311-312.
4. Green DM. The treatment of stages I-IV favorable
histology Wilms’ tumor. J Clin Oncol 2004; 22:
1366-1372.
5. Lam JS, Hensle TW, Debelenko L, Granowetter
L, Tennenbaum SY. Organ-confined primitive
neuroectodermal tumor arising from the kidney. J
Pediatr Surg 2003; 38: 619-621.
6. Mor Y, Nass D, Raviv G, Neumann Y, Nativ O, Goldwasser
B. Malignant peripheral primitive neuroectodermal
tumor (PNET) of the kidney. Med Pediatr Oncol 1994;
23: 437–440.
7. Jimenez RE, Folpe AL, Lapham RL, et al. Primary Ewing’s
sarcoma/primitive neuroectodermal tumor of the
kidney: a clinicopathologic and immunohistochemical
study. Am J Surg Pathol 2002; 26: 320–327.
8. Ellison DA, Parham DM, Bridge J, Beckwith JB.
Immunohistochemistry of primary malignant
neuroepithelial tumors of the kidney: a potential source
of confusion? A study of 30 cases from the National
Wilms Tumor Study Pathology Center. Human
Pathology 2007; 38: 205–211.
9. Rodriguez-Galindo C, Marina NM, Fletcher BD,
Parham DM, Bodner SM, Meyer WH. Is primitive
neuroectodermal tumor of the kidney a distinct entity?
Cancer 1997; 79: 2243–2250.
10. Erkilic S, Ozsarac C, Kocer NE, Erbagcı A. Primary
primitive neuroectodermal tumor of the kidney: a case
report. Int Urol Nephrol 2006; 38: 199–202.
11. Pomara G, Cappello F, Cuttano MG, et al. Primitive
neuroectodermal tumor (PNET) of the kidney: a case
report. BMC Cancer 2004; 4: 1-5.
12. Kuroda M, Urano M, Abe M, et al. Primary primitive
neuroectodermal tumor of the kidney. Pathol Int 2000;
50: 967–972.
13. Wang LL, Perlman EJ, Vujanic GM, et al. Desmoplastic
small round cell tumor of the kidney in childhood. Am
J Surg Pathol 2007; 31: 576–584.
14. Saxena R, Sait S, Mhawech-Fauceglia P. Ewing sarcoma/
primitive neuroectodermal tumor of the kidney: a
case report. Diagnosed by immunohistochemistry
and molecular analysis. Ann Diagn Pathol 2006; 10:
363–366.

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