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Maksiller diş etinde primer malign melanoma: olgu sunumu

Primary malignant melanoma of the maxillary gingiva: a case report

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2010

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Abstract (2. Language): 
SUMMARY Malignant melanoma of the oral cavity is extremely rare, accounting for 0.2% to 8% of all melanomas. Primary gingival malignant melanoma is associated with poor prognosis. We present the clinopathological findings of a case. A 64-year-old woman presented with a hyperplastic-pigmented lesion which was located on the right vestibular maxillary gingiva adjacent to the first molar-canine area. Under local anesthesia an incisional biopsy was taken from the lesion. The pathologic diagnosis of primary malignant melanoma of the gingiva was established after microscopic and immunohistochemical examination, which revealed the neoplastic cells to be positive for HMB-45. A computerized tomography scan on the neck, liver, and lungs revealed no further evidence of disease. A partial right maxillectomy with radical neck dissection was planned. The patient refused the treatment and died after 4 months. In malignant melanoma of the gingiva, survival rates may be increased by early diagnosis and treatment. The dentist must carefully examine periodontal tissues, and pigmented lesions should be biopsied
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Abstract (Original Language): 
Oral kavitedeki malign melanomlar bütün melanomların %0.2-8’sini oluş- turan çok nadir vakalardır. Primer gingival malign melanom kötü prognoza sahiptir. Bu çalışmada bir vakanın klinikopatolojik bulgularının sunulması amaçlanmıştır. Altmış dört yaşındaki kadın hastanın sağ maksiller vestibul diş etinde, birinci molar ve kanin dişe komşu hiperplastik pigmente lezyon mevcuttu. Lokal anestezi altında lezyondan insizyonel biyopsi alındı. Diş etinin primer malign melanomunun tanısı; mikroskobik inceleme ve immünohistokimyasal olarak HMB-45 pozitifliğinin saptanması ile konuldu. Boyun, akciğer ve karaciğerin tomografik incelemesinde hastalıkla ilgili bir bulguya rastlanmadı. Radikal boyun diseksiyonu ile birlikte sağ parsiyel maksillektomi planlandı, ancak hasta tedaviyi reddetti ve dört ay sonra öldü. Diş etinin malign melanomlarında sağ kalım süresi erken tanı ve tedaviyle artabilir. Diş hekimleri periodontal dokuları dikkatli muayene etmeli ve pigmente lezyonlardan biopsi almalıdırlar
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  • 3
208-211
  • English

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