You are here

Home » Content

Comparative study of cytology versus colposcopy to evaluate women who are positive on visual inspection test in rural medical college Bangalore

Journal Name:

  • Indian Journal of Basic & Applied Medical Research

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
ntroduction: Colposcopic evaluation and guided biopsy is an important diagnostic step and standard of management for abnormal cytology smears in developed countries. The present study evaluates the performance of colposcopy vs conventional cytology in estimating the presence and grade of cervical disease against the reference standard of histopathology as a secondary test modality to triage women found positive on primary screening by visual inspection with 5% acetic acid (via). Study Design: colposcopy and directed biopsy were performed after primary screening for cervical cancer in mvj medical college bangalore , india. Healthy women (7794) in the age group of 35-70 years participated in the cervical cancer early detection program in the hospital and community cancer screening clinics. women found positive on the primary screening test by via underwent diagnostic evaluation by pap smear cytology and colposcopy evaluation with directed biopsies. Accuracy parameters and their 95% confidence intervals were calculated using 2 χ 2 tables and standard formulae. RESULTS: Agreement between colposcopic impression and colposcopy directed biopsy,sensitivity - 57.14% specificity- 93.45% ,ppv -39.77% ,npv -96.64%. agreement between cytology and colposcopy directed biopsy. sensitivity - 49.20%specificity- 97.41%ppv- 59.04%npv- 96.20%
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon 990-997.pdf.pdf
  • 8
990-997
  • Turkish

REFERENCES

References: 

1. Shanta V, (2003). Perspectives in Cervical Cancer prevention in India. The International Network for
Cancer Treatment and Research .
2. Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence
Worldwide. IARC Cancer Base No.5. Version 2.0. Lyon: IARC Press; 2004
3. Sankaranarayanan R, Basu P, Wesley RS, Mahe C, Keita N, Mbalawa CC, et al (2004). Accuracy of visual
screening for cervical neoplasia: Results from an IARC multicentre study in India and Africa. Int J Cancer,
110, 907–13.
4. Sankaranarayanan R, Budukh A and Rajkumar R (2001). Effective screening programs for cervical cancer
in low- and middle-income developing countries. Bull World Health Organ, 79, 954–962.
5. Sankaranarayanan R, Rajkumar R, Arrossi S, Theresa R, Esmy PO, Mahe C, et al, (2003). Determinants of
participation of women in a cervical c.visual screening trial in rural south India. Cancer Detect Prev,27,
457-464
6. Guyot A, Karim S, Kyi MS, Fox J. Evaluation of adjunctive HPV testing by Hybrid Capture II in women
with minor cytological abnormalities for the diagnosis of CIN2/3 and cost comparison with colposcopy.
BMC Infect Dis 2003;3:23
7. Schiffman M, Solomon D. Findings to date from the ASCUS-LSIL Triage Study (ALTS). Arch Pathol Lab
Med 2003;127:946-9.
Indian Journal of Basic & Applied Medical Research; September 2013: Issue-8, Vol.-2, P. 990-997
996
www.ijbamr.com
8. Nanda K, McCrory DC, Myers ER, Bastian LA, Hasselblad V, Hickey JD, et al. Accuracy of the
Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review.
Ann Intern Med 2000;132:810-9
9. Wright TC Jr, Cox JT, Massad LS, Twiggs LB, Wilkinson EJ; ASCCP-Sponsored Consensus Conference.
2001 Consensus Guidelines for the management of women with cervical cytological abnormalities. JAMA
2002;287:2120-9.
10. Kurman RJ, Malkasian GD Jr, Sedlis A, Solomon D. From Papanicolaou to Bethesda: The rationale for a
new cervical cytologic classification. Obstet Gynecol 1991;77:779-82.
11. Reid R, Scalzi P. Genital warts and cervical cancer: VII: An improved colposcopic index for differentiating
benign papilloma viral infections from high-grade cervical intraepithelial neoplasia. Am J Obstet Gynecol
1985;153:611-8.
12. Sankaranarayanan R. Royal Society of Tropical Medicine and Hygiene meeting at Manson House, London
17 January 2002: Cervical cancer in developing countries. Trans R Soc Trop Med Hyg 2002;96:580-5.
13. University of Zimbabwe/JHPIEGO Cervical Cancer Project. Visual inspection with acetic acid for cervicalcancer
screening: Test qualities in a primary-care setting. Lancet 1999;353:869-73.
14. Sankaranarayanan R, Wesley R, Somanathan T, Dhakad N, Shyamalakumary B, Amma NS, et al. Visual
inspection of the uterine cervix after the application of acetic acid in the detection of cervical carcinoma
and its precursors. Cancer 1998;83:2150-6.
15. Sankaranarayanan R, Shyamalakumary B, Wesley R, Sreedevi Amma N, Parkin DM, Nair MK. Visual
inspection with acetic acid in the early detection of cervical cancer and precancers. Int J Cancer
1999;80:161-3.
16. Basu PS, Sankaranarayanan R, Mandal R, Roy C, Das P, Choudhury D, et al. Visual inspection with acetic
acid and cytology in the early detection of cervical neoplasia in Kolkata, India. Int J Gynecol Cancer
2003;13:626-32.
17. Sankaranarayanan R, Wesley R, Thara S, Dhakad N, Chandralekha B, Sebastian P, et al. Test
characteristics of visual inspection with 4% acetic acid (VIA) and Lugol's iodine (VILI) in cervical cancer
screening in Kerala, India. Int J Cancer 2003;106:404-8.
18. Shastri SS, Dinshaw K, Amin G, Goswami S, Patil S, Chinoy R, et al. Concurrent evaluation of visual,
cytological and HPV testing as screening methods for the early detection of cervical Neoplasia in Mumbai,
India. Bull World Health Organ 2005;83:186-94.
19. Arbyn M, Sankaranarayanan R, Muwonge R, Keita N, Dolo A, Mbalawa CG, et al. Pooled analysis of the
accuracy of five cervical cancer screening tests assessed in eleven studies in Africa and India. Int J Cancer
2008;123:153-60.
20. Syrjδnen KJ, Syrjδnen SM. Human Papillomavirus (HPV) typing as an adjunct to cervical cancer
screening. Cytopathology 1999;10:8-15.
Indian Journal of Basic & Applied Medical Research; September 2013: Issue-8, Vol.-2, P. 990-997
997
www.ijbamr.com
21. Arbyn M, Buntinx F, Van Ranst M, Paraskevaidis E, Martin-Hirsch P, Dillner J. Virologic versus
cytologic triage of women with equivocal Pap smears: A meta-analysis of the accuracy to detect high-grade
intraepithelial neoplasia. J Natl Cancer Inst 2004;96:280-93.
22. Arbyn M, Sasieni P, Meijer CJ, Clavel C, Koliopoulos G, Dillner J. Chapter 9: Clinical applications of
HPV testing: A summary of meta-analyses. Vaccine 2006;24:S78-89.
23. Nanda K, McCrory DC, Myers ER, Bastian LA, Hasselblad V, Hickey JD, et al. Accuracy of the
Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review.
Ann Intern Med 2000;132:810-9.
24. Sellors J, Sankaranarayanan R. Colposcopy and treatment of cervical intraepithelial neoplasia: A beginners'
manual. Lyon: IARC Press; 2003.
25. Mitchell MF, Schottenfeld D, Tortolero-Luna G, Cantor SB, Richards-Kortum R. Colposcopy for the
diagnosis of squamous intraepithelial lesions: A meta-analysis. Obstet Gynecol 1998;91:626-31.
26. Massad LS, Collins YC. Strength of correlations between colposcopic impression and biopsy histology.
Gynecol Oncol 2003;89:424-8.
27. Stafl A, Mattingly RF. Colposcopic diagnosis of cervical neoplasia. Obstet Gynecol 1973;41:168-76.
28. Hopman EH, Kenemans P, Helmerhorst TJ. Helmerhorst. Positive predictive rate of colposcopic
examination of the cervix uteri: An overview of literature. Obstet Gynecol Surv 1998;53:97-106.
29. Ferris DG, Miller MD. Colposcopic accuracy in a residency training program: Defining competency and
proficiency. J Fam Pract 1993;36:515-20.
30. Lozowski MS, Mishriki Y, Talebian F, Solitare G. The combined use of cytology and colposcopy in
enhancing diagnostic accuracy in preclinical lesions of the uterine cervix. Acta Cytol 1982;26:285-91.
31. Sideri M, Schettino F, Spinaci L, Spolti N, Crosignani P. Operator variability in disease detection and
grading by colposcopy in patients with mild dysplastic smears. Cancer 1995;76:1601-5.
32. Etherington IJ, Luesley DM, Shafi MI, Dunn J, Hiller L, Jordan JA. Observer variability among
colposcopists from the West Midlands region. Br J Obstet Gynaecol 1997;104:1380-4.
33. Sheshadri V, O'Connor DM. The agreement of colposcopic grading as compared to directed biopsy results.
J Low Genit Tract Dis 1999;3:150-4.

Thank you for copying data from http://www.arastirmax.com