Journal Name:
- Indian Journal of Basic & Applied Medical Research
Abstract (2. Language):
Background: Coronary artery disease (CAD) is the leading cause of morbidity & mortality worldwide and comprises mainly
stable angina, unstable angina & acute myocardial infarction . In the present study, we investigated plasma myeloperoxidase
(MPO) level along with uric acid and C-reactive protein (CRP) in patients with stable and unstable angina.
Methods: A total of 150 subjects were recruited and categorized into control group (n=50), stable angina (SA) group (n=50),
unstable angina group (n=50). Plasma myeloperoxidase level was measured by a modified sandwich ELISA assay, uric acid was
measured by enzymatic colorimetric reagents, CRP was measured by latex turbidity method assay
Results: Plasma Myeloperoxidase (MPO) levels were significantly increased in unstable angina (340.94 ± 45.28) and stable
angina (283.26 ± 30.68) as compared to control mean value (112.12 ± 29.07ng/ml). CRP was significantly raised in stable angina
[3.73 ± 0.72], and in unstable angina [18.22 ± 5.75] as compared to control mean value [1.39 ± .643mg/l]. While serum uric acid
levels were also significantly increased in unstable angina [5.58 ± 0.76], and stable angina [3.55 ± 0.62], when compared with
control mean value of uric acid [2.52 ± 0.51mg/dl].The values of MPO,CRP & Uric acid were also significantly higher in
unstable angina as compared to stable angina .
Conclusion: Myeloperoxidase level is increased in stable and unstable angina patients and this increase is statistically significant
when compared to the control group. Also this increase was in accordance with increase in other inflammatory marker like serum
CRP and serum uric acid. Similarly these values were also higher in unstable than stable angina. Hence myeloperoxidase serves
as a marker of the inflammation.
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