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Comparison of levels of Myeloperoxidase, C-reactive protein and Uric acid in patients of Stable and Unstable angina

Journal Name:

  • Indian Journal of Basic & Applied Medical Research

Publication Year:

  • 2013

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Abstract (2. Language): 
Background: Coronary artery disease (CAD) is the leading cause of morbidity & mortality worldwide and comprises mainly stable angina, unstable angina & acute myocardial infarction . In the present study, we investigated plasma myeloperoxidase (MPO) level along with uric acid and C-reactive protein (CRP) in patients with stable and unstable angina. Methods: A total of 150 subjects were recruited and categorized into control group (n=50), stable angina (SA) group (n=50), unstable angina group (n=50). Plasma myeloperoxidase level was measured by a modified sandwich ELISA assay, uric acid was measured by enzymatic colorimetric reagents, CRP was measured by latex turbidity method assay Results: Plasma Myeloperoxidase (MPO) levels were significantly increased in unstable angina (340.94 ± 45.28) and stable angina (283.26 ± 30.68) as compared to control mean value (112.12 ± 29.07ng/ml). CRP was significantly raised in stable angina [3.73 ± 0.72], and in unstable angina [18.22 ± 5.75] as compared to control mean value [1.39 ± .643mg/l]. While serum uric acid levels were also significantly increased in unstable angina [5.58 ± 0.76], and stable angina [3.55 ± 0.62], when compared with control mean value of uric acid [2.52 ± 0.51mg/dl].The values of MPO,CRP & Uric acid were also significantly higher in unstable angina as compared to stable angina . Conclusion: Myeloperoxidase level is increased in stable and unstable angina patients and this increase is statistically significant when compared to the control group. Also this increase was in accordance with increase in other inflammatory marker like serum CRP and serum uric acid. Similarly these values were also higher in unstable than stable angina. Hence myeloperoxidase serves as a marker of the inflammation.
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Indian Journal of Basic & Applied Medical Research; September 2013: Issue-8, Vol.-2, P. 897-902
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