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Paraoxonase 1, total cholesterol and HDL cholesterol in diabetes mellitus

Journal Name:

  • Indian Journal of Basic & Applied Medical Research

Publication Year:

  • 2013

Key Words:

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Abstract (2. Language): 
Background: Diabetes mellitus (DM) refers to a group of common metabolic disorder that shares the phenotype of hyperglycemia. The existence of hyperglycemia produces increased oxidative stress and associated with an increased risk of cardiovascular disease (CVD). The present study was planned to measure the serum levels of paraoxonase 1 (PON 1) activity, total and high density lipoprotein (HDL) cholesterol in patients with type 2 diabetes mellitus and to compare with healthy controls. Material and Methods: In this study total 80 subjects were included above 40 years of age. 40 clinically diagnosed type 2 diabetic patients and 40 normal subjects were recruited as control. PON 1 activity , total cholesterol and HDL cholesterol levels were measured by the methods of Therry FD et al and Lopes Virella M et al respectively.Data were analyzed using‘t’ test for their level of significance. Results:The mean PON 1 activity in type 2 diabetic patients was significantly lower than in the controls. The mean total cholesterol levels were significantly higher in patients as compared to the control subjects while the mean value of HDL cholesterol was significantly lower in type 2 diabetics when compared with controls. Conclusions: Reduced serum PON 1 activity, HDL cholesterol and elevated total cholesterol level might contribute to the increased susceptibility for the development of CVD in type 2 diabetic patients.
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  • 8
998-1001
  • English

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Indian Journal of Basic & Applied Medical Research; September 2013: Issue-8, Vol.-2, P. 998-1001
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