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inönü Üniversitesi Tıp Fakültesi Hastanesinde Hastane İnfeksiyonları

Nosocomial Infections in the Hospital of Inonu University Medical Faculty

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objectives: The aim of this study was to determine the distribution of microorganisms which were isolated as etiologic agents of nosocomial infections and to understand their antibiotic susceptibility patterns in our hospital. Methods: Between October 2001 and May 2002, nosocomial infections were determined by laboratory dependent surveillance system in the University Hospital, which has 750 bed capacities. Results: Between these dates, 294 hospital-acquired infections were detected in 193 patients from 8677 hospitalized patients. The nosocomial infection rate was found 3.4%. The infection rate was highest in the Newborn Unit (21%), the Internal Medicine Intensive Care Unit (14%), the Surgical Intensive Care Unit (11.5%) and the Pediatric Surgery (%10), respectively. The most common nosocomial infections observed were bacteremia (31.4%), which followed by respiratory system infections (30.3%) and urinary tract infections (20.2%). The most common etiologic agent was Staphylococcus aureus (%30.8). Methicillin resistant Staphylococcus aureus (MRSA) rate was 89.6% in nosocomial S. aureus strains. Ciprofloxacin and clindamycin resistance rates were 91.9% and 28% in 87 MRSA strains, respectively. Klebsiella spp. (12.1%), E. coli (7.9%) and Acinetobacter spp. (5.7%) were most common gram negative nosocomial infectious agents. Carbapenem, ceftazidime, ciprofloxacin resistances were found 12.5%, 50%, and 25% among Pseudomonas spp. strains, respectively. There was no resistance for ciprofloxacin and carbapenem (except one strain) in Klebsiella spp., but third generation cephalosporin resistance rate was 36%. Conclusion: MRSA rate is so high in S. aureus strains and prevention and control measurement for this microorganism must be performed immediately in our hospital. Also increasing ceftazidime and carbapenem resistance among Pseudomonas strains is taking attention.
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Abstract (Original Language): 
Amaç: Hastanemizde hastane infeksiyonu etkenlerinin dağılımının ve antibiyotiklere duyarlılıklarının belirlenmesi. Yöntem: Ekim 2001-Mart 2002 tarihleri arasında, bir üniversite hastanesi olan ve yaklaşık 750 yatak kapasiteli Tıp Fakultesi Hastanesinde, laboratuvara dayalı sürveyans yöntemi ile prospektif olarak nozokomiyal infeksiyonlar izlendi. Bulgular: Belirtilen tarihler arasında yatan 8677 hastanın 193'ünde 294 "hastane kökenli infeksiyon" tespit edildi. Genel infeksiyon hızı %3.4 olarak hesaplandı. Hastane infeksiyonlarının en sık; Yeni Doğan (%21), Dahili Yoğun Bakım (%14), Cerrahi Yoğun Bakım (%11.5) ve Peiatrik Cerrahi (%10) birimlerinde görüldüğü tespit edildi. İnfeksiyonların sistemlere göre dağılımı; bakteriyemi (%31.4), solunum sistemi (%30.3) ve üriner sistem infeksiyonları (%20.2) olarak saptandı. Hastane genelinde en sık izole edilen etken, %30.8 oranında Staphylococcus aureus idi. S. aureus suşları içinde metisiline dirençli Staphylococcus aureus (MRSA) oranı ise %89.6 olarak belirlendi. Seksen yedi MRSA suşunun %91.9'u siprofloksasine dirençli iken, %28'i klindamisine dirençli bulundu. Klebsiella türleri (%12.1), E. coli (%7.9) ve Acinetobacter türleri (%5.7) en sık izole nedilen Gram negatif mikroorganizmalardı. Pseudomonas suşlarında; karbapenemlere %12.5, seftazidime %50, siprofloksasine ise %25 oranında direnç vardı. Klebsiella suşlarında siprofloksasine ve bir suş dışında karbapenemlere direnç yok iken, 3. kuşak sefalosporinlere karşı %36 oranında direnç saptandı. Sonuç: Hastane infeksiyonu etkenleri arasında S. aureus suşları en sık tespit edilen etkenler olup MRSA oranının oldukça yüksek olduğu tespit edildi. Ayrıca Pseudomonas türleri ve diğer gram negatif bakterilerde artan karbapenem direnci ve Pseudomonas suşları arasında %50 'ye ulaşa seftazidim direnci dikkat çekici olarak değerlendirildi.
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  • 3
133-137
  • Turkish

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