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Kardiyovasküler Sistem ve Anjiotensin II Tip 2 Reseptörü (AT2)

Cardiovascular System and Angiotensin II Type 2 Receptor (At2)

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Abstract (2. Language): 
Angiotensin II, the effector peptide of the renin angiotensin system, regulates cellular growth in response to developmental, physiological, and pathological processes. It is well established that Angiotensin II has an important role in regulating cardiovascular hemodynamics and structure. Multiple lines of evidence have suggested the existence of at least two distinct Angiotensin II receptor subtypes, as ATı and AT2 receptors. Most of the known effects of Angiotensin II in cardiovascular tissues are attributable to the ATı receptor, but less is known about the AT2 receptor. ATı and AT2 receptors may exert opposite effects in terms of cell growth and blood pressure regulation. Herein, we will discuss the role of the AT2 receptor in the cardiovascular system.
Abstract (Original Language): 
Anjiotensin II (AII) gelişimsel, fizyolojik ve patolojik süreç içinde hücresel büyümeyi düzenlemekle birlikte, renin-anjiotensin sisteminin de etkili bir peptididir. Ali'nin kardiyovasküler hemodinamiyi düzenlemesindeki rolü oldukça güçlü şekilde kanıtlanmıştır. Birçok çalışmada ATı ve AT2 reseptörleri şeklinde tanımlanan, birbirinden farklı en az 2 tane Anjiotensin II reseptör subtipi olduğu ortaya konulmuştur. AII kardiyovasküler sistem (KVS) üzerindeki pek çok etkisini ATı reseptörü üzerinden gerçekleştirmekte olup, AT2 reseptörünün katkısı ise çok fazla bilinmemektedir. ATı ve AT2 reseptörlerinin, hücre büyümesi ve kan basıncı düzenlenmesinde birbirine zıt etkileri vardır. Biz bu derlemede AT2 reseptörlerinin KVS üzerindeki etkilerini ele alacağız.
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