Paratiroid Hormon İlişkili Proteine Bağlı Malin Hiperkalsemiyle Başvuran Meduller Tiroid Karsinomu Olgusu
Journal Name:
- İnönü Üniversitesi Tıp Fakültesi Dergisi
Key Words:
Keywords (Original Language):
Author Name | University of Author | Faculty of Author |
---|---|---|
Abstract (2. Language):
We present the case of a 50-year-old male patient presenting with a mass lesion in the neck region and diarrhea.
Histological examination of the excisional biopsy specimen revealed medullary thyroid carcinoma. In the laboratory
examination of the patient marked hypercalcemia was detected along with a low parathyroid hormone (PTH) levels
(<1 pg/ml, (normal range: 10-69 pg/ml). PTH-related protein (PTHrP) level was elevated (8.5 pmol/L, normal
range: <1.3 pmol/L). An extensive metastasis screening found metastatic lesions in the liver while no bone
metastasis was discovered. The patient died shortly after induction of chemotherapy due to respiratory failure. To
the best of our knowledge, this is the first reported case of a PTHrP-producing medullary carcinoma of the thyroid
associated with humoral hypercalcemia of malignancy.
Bookmark/Search this post with
Abstract (Original Language):
Burada boyunda kitle ve diyare ile başvuran 50 yaşında bir erkek hastayı sunduk. Kitleden alınan eksizyonel biopsi
örneğinin histolojik incelemesinde meduller tiroid karsinomu saptandı. Gelişindeki laboratuvar tetkiklerinde belirgin
hiperkalsemi saptanan hastanın serum paratiroid hormon (PTH) düzeyi <1 pg/ml (normal: 10-69), PTH-ilişkili
protein (PTHrP) düzeyi ise 8.5 pmol/L (normal: <1.3) bulundu, ayrıca karaciğerde metastaz saptandı, kemik
metastazı tespit edilmedi. Kemoterapi başlanan hastanın durumu progressif olarak kötüleşti ve solunum yetmezliği
nedeniyle kaybedildi. Olgumuz literatürde PTHrP üretimine bağlı malign humoral hiperkalseminin nedeni olarak
bildirilen ilk meduller tiroid karsinomu olgusudur.
FULL TEXT (PDF):
- 4
263-266