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Vitiligolu Hastaların Serum Yağ Asidi Kompozisyonunun İncelenmesi

Investigation of Serum Fatty Acids’ Composition in Patients With Vitiligo

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objectives: Vitiligo is an acquired skin disorder resulting from the loss of functional melanocytes and is characterized by depigmented macular lesions. The etiopathogenesis of vitiligo has not been explained exactly yet. As a result of the studies that have been made for clarifying this mechanism, three basic theories have been suggested. Autoimmune theory, neural theory and autocytotoxic theory. In this issue, there are a lot of studies and several studies have been continued. Some of the present studies show that inflammatory parameters involves in vitiligo. As known, arachidonic acid is a PUFA and a key molecule for inflammation. In the literature, there is not a comprehensive study that investigates the relation between polyunsaturated fatty acid (PUFA) and vitiligo formation. Patients and Methods: In this study we aimed to investigate the possible relationship between vitiligo etiopatogenesis and serum fatty acids’ composition. In this way we studied serum fatty acids’ levels in healthy and patients with generalized active vitiligo. Serum fatty acids’ levels were transformed to their methylesters, then analysed by gas cromotography. Results and Conclusion: We found that serum fatty acid levels except two kinds were similar to those of healty controls. On the other hand, palmitoleic acid levels were found decreased and Docosapenthaenoic acid levels were found increased (p<0.05). But, in general, our results clearly show that the serum composition of fatty acids in patients with generalized active vitiligo are not significantly different from those of healthy controls.
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Abstract (Original Language): 
AMAÇ: Vitiligo fonksiyonel melanositlerin kaybı sonucu oluşan ve depigmente maküler lezyonlarla karakterize bir tür deri hastalığıdır. Oluşum mekanizması henüz aydınlatılabilmiş değildir. Bu mekanizmayı aydınlatabilmek üzere yapılan çalışmalar sonucunda 3 temel teori öne sürülmüştür; otoimmün teori, nöral teori ve otositotoksik teori. Bu doğrultuda araştırmacılar tarafından pek çok çalışma yapılmıştır ve yapılmaya devam etmektedir. Mevcut çalışmaların bir kısmı vitiligoda inflamasyonla ilişkili parametrelerin etkili olabileceği yönündedir. Bilindiği gibi, araşidonik asit çoklu doymamış bir yağ asididir (PUFA) ve inflamasyon prosesinde anahtar moleküldür. Literatürde vitiligo gelişimi ile doymamış yağ sitleri arasındaki ilişkiyi araştıran karşılaştırmalı bir çalışma bulunmamaktadır. YÖNTEM: Bu çalışmada serum yağ asidi kompozisyonu ile vitiligo oluşum mekanizması arasındaki olası ilişkinin araştırılması amaçlandı. Bu doğrultuda aktif generalize vitiligolu hastalar ile sağlıklı bireylerin serum yağ asidi düzeylerine bakıldı. Serum yağ asitleri önce yağ asidi metil esterlerine dönüştürüldü ve sonra gaz kromotografisi ile analiz edildi. SONUÇLAR VE YORUM: On yağ asidi düzeyinden ikisi dışındakiler kontrol gurubu ile aynı düzeylerde bulundu. Palmitik asit düzeyi kontrol gurubuna göre azalmış ve dokosapentaenoik asit düzeyleri ise kontrole göre artmış (p<0,05) olarak tespit edildi. Fakat, genel olarak aktif vitiligolu hastalar ile sağlıklı kontrol grubu arasında serum yağ asidi düzeyleri bakımından dikkate değer bir farklılık belirlenemedi.
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  • 3
145-149
  • Turkish

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