You are here

Home » Content

Malatya Bölgesinde Cerrahi Uygulanmış Tiroid Papiller Kanserlerinin Histopatolojik Alt Grupları

Histopathologic Subtypes of Surgically Resected Papillary Thyroid Carcinomas in Malatya Region

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Abstract: Retrospective analysis of histologic subtypes of papillary thyroid carcinoma (PTC). Material and Method: Histopathology reports at the Department of Pathology, Inönü University, Medical School Malatya, Turkey revealed 33 papillary thyroid carcinoma (PTC) cases in a nine year period. Results: The demographic findings (23 females, 10 males with an average age of 45) were similar to previous reports but the distribution of the PTC subtypes showed some variation. The number and percentage of the PTC subtypes were as following: encapsulated 8 (24%), tall cell 7(21%), follicular 7 (21%), macrofollicular 5 (15%), oncocytic 3 (9%) and micro-carcinoma 3 (9%). Though the total number of the cases is not suitable for a statistical analysis incidence of the aggressive variant i.e. tall cell subtype is remarkable when compared to other series published. Lymph node metastasis was detected predominantly in the oncocytic (66.7%) and tall cell (%57.1%) subtypes. Conclusion: Tall cell and oncocytic PTC must be distinguished in the surgical pathology reports precisely for clinical evaluation due to high frequency of lymph node metastasis.
Bookmark/Search this post with
Abstract (Original Language): 
Amaç: Papiller tiroid kanseri (PTK) alt gruplarının retrospektif analizi. Gereç ve Yöntem: Malatya İnönü Üniversitesi Tıp Fakültesi, Patoloji Laboratuarı arşivinde dokuz yıllık zaman dilimi içinde cerrahi girişimle tiroidektomi uygulanmış 33 adet PTK olgusu değerlendirildi. Bulgular: Demografik verilerin (23 kadın, 10 erkek, ortalama 45 yaş ) daha önce bildirilmiş özelliklere uyduğu görüldüyse de PTK histopatolojik alt gruplarında farklılıklar tespit edildi. PTK alt gruplarında sıklık sırasıyla, kapsüllü 8 (%24), yüksek hücreli 7 (%21), folliküler 7 (%21), makrofolliküler 5 (%15), onkositik 3 (%9) ve mikrokarsinom 3 (%9) izlendi. Toplam hasta sayısı istatiksel analize olanak vermese de kötü gidişli kabul edilen yüksek hücreli alt grup yayınlanmış serilerdekilerden fazladır. Lenf düğümü metastazları en fazla sırasıyla onkositik (%66.7) ve yüksek hücreli (%57.1) gruplarda izlendi. Sonuç: PTK içinde sık lenf düğümü yayılımı nedeniyle onkositik ve yüksek hücreli alt grupların patoloji raporlarında ayırd edilerek belirtilmesi ve klinik değerlendirmenin gerekliliği ortaya çıkmaktadır
FULL TEXT (PDF): 
PDF icon arastirmax-malatya-bolgesinde-cerrahi-uygulanmis-tiroid-papiller-kanserlerinin-histopatolojik-alt-gruplari.pdf
  • 2
77-80
  • Turkish

REFERENCES

References: 

1. Rosai J, Carcangiu ML, DeLellis RA. Tumors of the thyroid
gland. In Rosai J, Sobin LE, ed(s). Atlas of Tumor Pathology.
Third series. Fascicle 5. Washington DC: AFIP, 1992.
2. Chan JKC. Tumors of the thyroid and parathyroid glands. In
Fletcher CDM (ed), Diagnostic Histopathology of Tumors. 3rd
ed. Churchill Livingstone-Elsevier, 2007:997-1080.
3. Özgültekin R, Emirleroğlu M. Diferansiye tiroid kanserlerinde
cerrahi patoloji. Düren M (ed), Tiroid Kanseri. Nobel Tıp
Kitapevi, İstanbul, 2005:35-47.
4. Öcal K, Canbaz H, Dirlik M, Aydın Ö, Türkmenoğlu Ö,
Çağlıkülekçi M, Aydın S. Tiroid mikropapiller karsinom sıklığı.
Mersin Ünv. Tıp Fak Dergisi 2002;3:298-302.
5. DeLellis RA, Lloyd RV, Heitz PU, et al eds. World Health
Organization Classification of Tumours, Pathology and
Genetics of Tumours of Endocrine Organs. Lyon: IARC, 2004.
6. Nikiforov YE, Ohori NP. Papillary carcinoma, in: Nikiforov
YE, Biddinger PW, Thompson LDR (eds), Diagnostic
Pathology and Molecular Genetics of the Thyroid, Lippincott
Williams and Wilkins, 2009:160-213
7. Ries LAG, Melbert D, Krapcho M, et al. SEER Cancer
Statistics Review, 1975-2004. (Based on November 2006 SEER
data submission.) National Cancer Institute. Bethesda, MD.
Available at: http://seer.cancer.gov/csr/
8. Parkin DM, Bray F, Ferlay J. Global cancer statistics 2002. CA
Cancer J Clin 2005;55:74-108.
9. Terry JH, St John SA, Karkowski FJ, Suarez JR, Yassa NH,
Platica CD, Marti JR. Tall cell papillary thyroid cancer: incidence
and prognosis. Am J Surg 1994;168(5):459-61.
10. Segal K, Friedental R, Lubin E, Shvero J, Sulkes J, Feinmesser
R. Papillary carcinoma of the thyroid. Otolaryngol Head Neck
Surg 1995;113:356-63.
11. Pilotti S, Collini P, Manzari A, Marubini E, Rilke F Poorly
differentiated forms of papillary thyroid carcinoma, distinctive
entities or morphological patterns? Semin Diagn Pathol
1995;12:249-55.
12. Khan AR, Abu-Eshy SA.Variants of papillary carcinoma of the
thyroid. J R Coll Surg Edinb 1998;43:20-25.
13. Muzaffar MA, Nigar E, Mushtaq S, Mamoon N. The
morphological variants of papillary carcinoma of the thyroid: a
clinico-pathological study--AFIP experience. Pak Med Assoc
1998;48:133-7.
14. Eyibilen A, Aladag I, Guven M, Kosboglu RD. Surgical
approach to encapsulated follicular variant of papillary thyroid
carcinoma, report of three cases. Kulak Burun Bogaz Ihtisas
Derg 2008;18:384-8

Thank you for copying data from http://www.arastirmax.com