Atypical Presentation of Herpes Zoster Infection Following Fludarabine Treatment for Chronic Lymphocytic Leukemia: A Case Report
Journal Name:
- İnönü Üniversitesi Tıp Fakültesi Dergisi
Keywords (Original Language):
Abstract (2. Language):
Herpes zoster (zona) is an infection with acute vesicular eruption due to the varicella zoster virus. A painful skin rash
characterizes herpes zoster, with dermatomal distribution in a limited area on one side of the body. A 49-year-old
Caucasian male with chronic lymphocytic leukemia presented with sudden onset of painful vesicles on the right
abdomen. He was receiving fludarabine for the treatment of Chronic lymphocytic leukemia. The patient was
neutropenic and diagnosed as zona zoster based on history and physical examination; acyclovir treatment was initiated.
After 3 days of the treatment he developed florid disseminated erythematous vesicles over his entire body, including
the face and scalp. Tzanck smear showed varicella zoster. Despite acyclovir treatment diffuse infiltration was observed
in the lungs of the patient, with hyperthermia and dyspnea. Pneumonia was consisted with thoracic computed
tomography. The patient’s hyperthermia did not respond to teikoplanin, meropenem and intravenous
immunoglobulin. He died.
Bookmark/Search this post with
Abstract (Original Language):
Herpes zoster (zona), varisella zoster virüsünün neden olduğu akut veziküler erüpsiyon ile seyreden bir infeksiyondur.
Dermatomal dağılımla sınırlı, tek taraflı ve ağrılı döküntülerle karakterizedir. 49 yaşında, Kafkasyalı, erkek hastada
kronik lenfositik lösemi nedeni ile fludarabin tedavisi alırken karının sağ tarafında ağrılı veziküller oluştu. Nötropenik
olan hastaya anamnez ve izik muayene ile zona tanısı kondu ve asiklovir tedavisi başlandı. Tedavinin 3. gününde
hastanın yüz ve kafa derisi dahil tüm vücüdunda yaygın eritematöz veziküller gelişti. Tzanck testi ile varisella zoster
olduğu gösterildi. Asiklovir tedavisine rağmen hastanın akciğerinde diffüz infiltrasyon izlendi, hipertermi ve dispne
meydana geldi. Toraks tomoğrafisi pnömoni ile uyumlu idi. Hastanın hipertermisi teikoplanin, meronepem ve
intravenöz immünglobuline cevap vermedi. Hasta öldü.
FULL TEXT (PDF):
- 4
281-283