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Solid Tümörleri n Tedavisinde Otolog Kemik İliği Transplantasyonu

Bone marro w transplantation in the treatment of solid tumors

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Abstract (2. Language): 
In the last ten years, autologous bone marrow transplantation in the treatment of malignant disease has been increasingly used. This procedure is limited to the 20-25 % of the cases where HLA-ABC and DR tissue groups are suitable for performing allogeneic bone marrow transplantation. Therefore, in the cases in whom conventional dose chemotherapies can not provide a complete remission, high-dose chemotherapies have often been used through autologous bone marrow transplantation. This therapy has been performed in malignancies such as lymphomas, multiple myelomas, small cell lung cancers, ovarian and germ cell cancers, neuroblastomas, malignant melanomas, rhabdomyosarcomas, Ewing sarcomas and breast cancers recently.
Abstract (Original Language): 
Son on yıldır, malign hastalıkların tedavisinde otolog kemik iliği transplantasyonu, giderek artan bir oranda kullanılmaktadır. HLA-ABC ve DR doku grubu uygunluğu olan kişileri bularak, allojenik kemik iliği transplantasyonu gerçekleştirmek % 20-25 oranı ile sınırlıdır. Bu nedenle klasik dozlardaki kemoterapilerin tam remisyon sağlayamadıkları olgularda, otolog kemik iliği transplantasyonu yardımıyla, daha yüksek dozlarda kemoterapi uygulamak giderek daha sık başvurulan bir tedavi yöntemi olmaktadır. Bu tedavi yöntemi son yıllarda lenfomalar, multiple myeloma, küçük hücreli akciğer kanserleri ve germ hücreli kanserlerle, neuroblastoma, malign melanoma, rhabdomyosarkom, Ewing sarkomu ve meme kanseri gibi birçok malignitede kullanılmaktadı
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