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Non-Hodgkin Lenfomalı Hastalarda Kemik İliği ve Periferik Stem Cell Ürünlerinin İnterleukin-2'ye Cevaplarının Karşılaştırılması

The comparison of the responses of bone marrow and peripheral stem cell products from patients with non-Hodgkin lymphoma to interleukin-2

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1996

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
The immune response to interleukin-2 (IL-2) differs between autologous bone marrow (BM) and granulocyte-monocyte colony stimulating factor (GM-CSF) mobilized peripheral stem cell (PSC) products as well as compared to normal peripheral blood leukocytes (PBL). Stem cell products from 24 patients with non-Hodgkin's lymphoma (NHL) were examined both before and following 5 days co-incubation with IL-2, and the cell proliferation in response to IL-2 were examined. These studies show that the IL-2 stimulated proliferative response of PSC was not different than observed with normal PBL, but there was statistically significant decrease between not only PBL and BM but also PSC and BM (p=0.0136 and p=0.0179, respectively). As these results show, ex vivo threat of PSC with IL-2 before PSC transplantation is capable of to increase defective-lymphocyte function. Therefore, the use of PSC transplantation as compared to BM transplantation for hematologic reconstitution is superior. [Journal of Turgut Özal Medical Center 1996;3(2):75-79]
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Abstract (Original Language): 
lnterleukin-2 (IL-2) 'ye immün cevap, normal periferal kan lökositleri (PBL) ile karşılaştırılınca otolog kemik iliği (BM) ve granülosit-monosit koloni stimülan faktör (GM-CSF) ile mobilize edilmiş periferik stem cell (PSC) ürünlerinde farklıdır. Non-Hodgkin lenfomalı 24 hastadan elde edilen stem cell ürünlerinin IL-2 ile kültürden önce ve 5 gün IL-2 ile birlikte kültür yapılarak hücre proliferasyonu incelendi. Bu çalışmalara göre PSC'in IL-2 tarafından stimüle edilen proliferatif cevabı normal PBL'den farklı değilken hem PBL ve BM (p=0.0136) hem de PSC ve BM (p=0.0179) arasındaki fark PBL'den istatistiki olarak anlamlı derecede farklı idi. Bu sonuçlar, PSC'deki defektif lenfositlerin transplantasyondan önce in vitro IL-2 ile muamele edilmesi ile düzeltilebileceğini göstermektedir. Bu nedenle hematolojik rekonstitüsyon için PSC transplantasyonu, BM transplantasyonuna üstündür. [Turgut Özal Tıp Merkezi Dergisi 1996;3(2):75-79]
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  • 2
75-79
  • Turkish

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