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Spinal metastazh malign melanomalarin nörolojik bulguları

Neurological Manifestation of Spinal Metastasis of Malignant Melanoma : Clinical Analysis of 26 Patients

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1997

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Although malignant melanoma is one of the most common causes of central nervous system metastases, spinal metastases from it are relatively rare. Despite spinal metastases primarily are not fatal, they may be catastrophic because of ambulation loss and sphincter disturbances. The purpose of this study was to review the course of this illnes after the development of neurological deficits and to asses the efficiacy of radiation therapy on symptoms and signs of spinal metastasis. 26 patients with neurological manifestations from spinal metastasis of melanoma were analyzed retrospectively. Median age of the patients was 48 years (range 24-87). Fifteen patients had cord compression by epidural metastasis, 6 patients had intramedullary, and 5 patients had leptomenengial metastasis. 17 of these patients suffered from pain. In 12 patients, first symptom was neurological disturbance, while in 14 patients it was pain. In patients who received radiotherapy for pain, in 5 patients pain improved, in 13 patients remained unchanged, in 2 patients worsened. In patients who received radiotherapy for neurological deficits, in 9 patients deficit improved, in 7patients worsened, in 10 patients did not change. While radiotherapy had significant effect on neurological recovery (p<0.03), it did not have any effect on pain. [Journal of Turgut Özal Medical Center 1997;4(1):21-25]
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Abstract (Original Language): 
Merkezi sinir sistemine sıklıkla metastaz yapan tümörlerden biri olmasına rağmen, malign melanomalarin spinal metastazları kısmen nadirdir. Primer olarak ölümcül olmayan spinal metastazlar, hastanın ambülasyonımda bozukluklara ve sfinkter kusurlarına neden olarak, oldukça sıkıntılı bir tablo oluşturabilirler. Bu çalışmanın amacı, bu hastalığın, nörolojik tablo geliştikten sonraki seyrini belirliyerek, radyoterapinin semptomlar ve nörolojik bozukluklar üzerine etkinliğini araştırmaktır. Malign melanoma'nın spinal metastazının, nörolojik bozukluk yaptığı 26 hasta retrospektif olarak analiz edildi. Median yaş 48 'di (24-87 arası). 15 hastada epidural metastaza bağlı kord kompresyonu, 6 hastada intrameduller, 5 hastada leptomenenjial metastaz vardı. Bu hastaların 17'sinde ağrı şikayeti mevcuttu. 12 hastanın ilk şikayeti nörolojik bozukluklar iken, 14 hastada ilk şikayet ağrıydı. Ağrı şikayeti olup ta radyoterapi yapılan hastaların 5'inde ağrı kayboldu veya azaldı, 13'ünde değişmedi, 2'sinde arttı. Radyoterapi yapılan hastaların, 9'unda nörolojik defisitler düzelirken, 7'sinde arttı, 10'unda değişmedi. Radyoterapinin, nörolojik düzelme üzerine önemli derecede etkisi varken (p<0.03), ağrı üzerine herhangi bir etkisi olmadığı saptandı. [Turgut Özal Tıp Merkezi Dergisi 1997;4(1):21-25]
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