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Endemik Guatrlı Hastalarda Tiroid Antikorları

Anti-thyroid antibodies in patients with endemic goitre

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Anti-thyroid antibodies may be present in patients with endemic goitre. We evaluated the levels of antimicrozomal (anti-M), and antithyroglobulin (anti-T) antibodies in 41 patients with endemic goitre and 15 healthy subjects. Anti-M levels were negative in all healthy subjects while 9 (21.95%) of 41 patients had positive titers (G1b; 7.3%, G2; 9.75%, G3; 4.87%). Anti-T levels were within normal range in healthy subjects, and patient groups of G1b, and G2. But it was elevated in patient group G3 (178.85188.44 U/ml). Anti-T values were correlated directly with goitre size (p<0.001). Consequently, thyroid antibodies may be increased with an unknown mechanism in iodine-deficient patients. [Journal of Turgut Özal Medical Center 1998;5(1):30-33]
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Abstract (Original Language): 
Endemik guatrda tiroid antikorları artabilmektedir. Bu çalışmada Malatya ilinde yaşayıp, polikliniğimize başvuran ve değişik derecelerde guatrı olan 41 hasta ile 15 sağlıklı kontrol grubunda antimikrozomal (anti-M) ve antitiroglobulin (anti-T) antikorlarının düzeyi araştırıldı. Çalışmamızda anti-M düzeylerini kontrol grubundaki bireylerin tümünde negatif, hasta grubunda ise toplam 41 hastanın 9'unda (%21,95) pozitif olarak saptadık. Bu pozitiflik oranı G1b grubunda %7.3, G2'de %9.75, G3'de ise %4.87 idi. Anti-T düzeyleri ise kontrol grubunda ve hastalarımızın G1b ve G2 gruplarında normal sınırlarda iken G3grubunda normal değerinin yaklaşık iki katına (178,85188,44 U/ml) ulaşıyordu. Anti-T değerleri guatr büyüklüğü ile doğru orantılı artış gösteriyordu (p<0.001). Sonuçlarımız iyot eksikliğinde artış mekanizması tam olarak bilinmese de tiroid antikorlarının artabileceğini göstermektedir. [Turgut Özal Tıp Merkezi Dergisi 1998;5(l):30-33]
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  • 1
30-33
  • Turkish

REFERENCES

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