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HAFİF VE ORTA ŞİDDETLİ MİTRAL DARLIĞI OLAN SİNÜS RİTMİNDEKİ HASTALARDA METOPROLOL VE DİLTİAZEMİN ETKİNLİĞİ

Efficacy of metoprolol and diltiazem in patients with mild and moderate mitral stenosis in sinus rhythm

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
This study was performed to evaluate the effects of metoprolol and diltiazem on exercise capacity and hemodynamic parameters in 64 patients with mild and moderate mitral stenosis in sinus rhythm. All patients were randomized to metoprolol group and diltiazem group. At the beginning and at the end of each treatment period, a treadmill exercise and M-mode, two dimensional, and Doppler echocardiography were performed. Only metoprolol significantly reduced the peak and mean transmitral gradient and heart rate (P<0.01, P<0.05, and P<0.05, respectively) and also significantly increased exercise time, whereas diltiazem did not change these parameters at all. Yazışma Adresi: Dr.Sait ALAN Yüksek İhtisas Hastanesi Kardiyoloji Kliniği ANKARA In conclusion, symptomatic improvement in patients with mild and moderate mitral stenosis in normal sinus rhythm was observed in metoprolol group compared with diltiazem group
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Abstract (Original Language): 
Bu çalışma sinüs ritmli hafif ve orta şiddetli mitral darlığı olan 64 hastada egzersiz kapasitesi ve hemodinamik parametreler üzerine metoprolol ve diltiazemin etkisini değerlendirmek için yapıldı. Tüm hastalar metoprolol ve diltiazem grubu olarak randomize edildi. Her tedavi periodunun başlangıcında ve sonunda tredmil egzersiz testi ve M-mode, iki boyutlu ve doppler ekokardiografi yapıldı. Sadece, metoprolol pik ve ortalama transmitral gradiyentini ve kalp hızını önemli derecede azaltı (sırasıyla, P<0.01, P<0.05 ve P<0.05 ) ve aynı zamanda, egzersiz süresini önemli oranda artırdı. Diltiazem ise bu parametrelerin hiçbirini değiştirmedi. Sonuç olarak, normal sinüs ritmli hafif-orta şiddetli mitral darlığı olan hastalarda semptomatik düzelme, diltiazem grubuyla karşılaştırıldığında metoprolol grubunda gözlend .
FULL TEXT (PDF): 
PDF icon arastrmx_5674_6_pp_130-135.pdf
  • 2
130-135
  • Turkish

REFERENCES

References: 

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