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AKTİF BEHÇET HASTALIĞI OLAN HASTALARDA LIPOPROTEIN (A) VE LİPİD PARAMETRELERİNİN DEĞERLENDİRİLMESİ

Evaluation of the lipoprotein (a) and other lipid parameters in patients with active Behçet's disease

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Behçet's disease is characterized by recurrent ulcerations of the mouth, skin lesions, ocular manifestations and ulcers of the genitalia. Recurrent thrombophlebitis and trombosis may occur in the disease. Lipoprotein (a) is a LDL-like particule with a large glycoprotein called apo/ipoprotein (a). The unique structural features of lipoprotein (a) give it the potential for atherogenic and thrombogenic activities. Plasma levels of other lipid parameters are important for atherogenesis and trombosis, too. The aim of this study was to investigate the relationship between lipoprotein (a) and the others lipid parameters with active Behçet's disease. Twelve patients with active Behçet's disease and age-matched, healthy 12 persons were the subjects of this study. There were no statistically significant differences between patients and control groups for lipoprotein (a) and total cholesterol levels (p>0.05). There were significant increase in HDL-C, LDL-C and triglycerides in patient group (p<0.05). We concluded that plasma lipid levels may increase in Behçet's disease and this elevation may cause increased vascular complications.
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Abstract (Original Language): 
Behçet hastalığı, oral ve genital ülserler, deri bulguları ve göz belirtileriyle karakterize bir hastalıktır. Tekrarlayan tromboflebit ve tromboz da görülebilir. Lipoprotein(a), apo/ipoprotein (a) olarak adlandırılan glikoprotein yapısıyla LDL'ye benzeyen bir maddedir. Lipoprotein (aynın yapısal özellikleri potansiyel atherogenik ve trombogenik aktivite göstermesine neden olur. Ayrıca, diğer plazma lipid düzeyleri de atherogenezis ve trombogeneziste önemlidir. Bu çalışmada, aktif Behçet hastalığı ile lipoprotein (a) ve diğer lipidlerin ilişkisinin olup olmadığının belirlenmesi amaçlanmıştır. Bu amaçla aktif Behçet hastalığı olan 12 olgu ve sağlıklı 12 kişi çalışmaya alındı. Lipoprotein (a) ve total kolesterol yönünden hasta ve kontrol grubu arasında istatistiksel olarak anlamlı fark yoktu (p>0.05). Hasta grubunda HDL-C, LDL-C ve trigliserit düzeyleri anlamlı düzeyde yüksek bulundu (p<0.05). Sonuç olarak, Behçet hastalığında plazma lipid düzeylerinde artma görülebilir ve bu artış vasküler komplikasyonların habercisi olabilir.
FULL TEXT (PDF): 
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  • 3
233-236
  • Turkish

REFERENCES

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