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MELANİN VE KİMYASALLAR

Melanin and chemicals

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Melanin is a polymer of quinone and hydroquinone monomer units found throughout the animal and plant kingdoms. In addition to its function in pigmentation, melanin also binds various drugs and chemicals in animals. With this function, melanin protects the pigmented cells and adjacent tissues by absorbing harmful substances, which then are slowly released in nontoxic concentrations. Long-term exposure, on the other hand, builds up high levels of noxious chemicals, stored on the melanin, which ultimately causes degeneration in the melanin-containing cells, and secondary lesions in surrounding tissues. In the eye and in the inner ear, the pigmented cells are located close to the receptor cells, and melanin binding may be an important factor in the development of some ocular and inner ear lesions. In the brain, neuromelanin is present in nerve cells in the extrapyramidal system, and melanin affinity of certain neurotoxic agents may be involved in the development of parkinsonism and tardive dyskinesia. There also seems to be a correlation between the induction of melanoma and melanin affinity of carcinogenic compounds found in the pigment cells of animals.
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Abstract (Original Language): 
Melanin, hayvan ve bitki aleminde yaygın olarak bulunan, kinon ve hidrokinon monomer-lerinden oluşmuş bir polimerdir. Hayvanlarda pigmentasyon işlevinden başka, çeşitli ilaç ve kimyasal maddeleri kendisine bağlamaktadır. Melanin bu şekilde zararlı maddeleri absorbe etmekte ve sonradan toksik olmayan konsantrasyonlarda yavaş olarak etrafa bırakarak, hem pigment hücrelerini hem de çevre dokuları korumaktadır. Diğer yandan, yüksek miktarda zararlı kimyasal birikimi, melanin içeren hücrelerde ve çevre dokularda hasara yol açmaktadır. Örneğin gözde ve iç kulakta bulunan pigment hücreleri, duyu hücrelerine yakın yerleşmiş ve melanine bağlanma bazı oküler ve iç kulak lezyonlarının gelişmesinde önemli bir faktör olabilmektedir. Beyinde ise, çeşitli nörotoksik ajanların ekstrapiramidal sistemdeki sinir hücrelerinde bulunan nöromelanine bağlanması, parkinsonizm ve tardiv diskinezi gelişimine neden olmaktadır. Ayrıca, hayvanların pigment hücrelerinde biriken bazı karsinojenik bileşiklerin malign melanoma gelişimine de neden olduğu düşünülmektedir.
FULL TEXT (PDF): 
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  • 1
87-91
  • Turkish

REFERENCES

References: 

1. Sadler
TW
. Langman's Medikal Embriyoloji; 6ncı baskı. Ankara: Palme Yayıncılık. 1993: 62-3.
2. Murray RK, Granner DK, MayesPA, et al. Harper's Biochemistry. 24th ed. Connecticut: Appleton&Lange. 1996: 339-40.
3. Goldgeier MH, Klein LE, Klein-Angerer S, Moellmann G, Nordlung JJ. The distribution of melanocytes in the leptomeninges of the human brain. J Invest Dermatol 1984; 82: 235-8.
4. Junqueira LC, Carnerio J, Kelley RO. Basic Histology. 9th ed. Connecticut: Appleton&Lange. 1998: 350-2.
5. Tammela M. Tissue localisation of some organic and inorganic cautions. Binding to melanin and cartilage. Acta Universitatis Upsaliensis 1985; 111: 1-42.
6. Larsson B. Interaction between chemicals and melanin. Pigment Cell Res 1993; 6: 127-33.
7. Larsson B, Tjalwe H. Studies on the melanin affinity of metal ions. Acta Physiol Scand 1978; 104: 479-84.
8. Prota G. Melanins and melanogenesis. New York: Academic Press. 1992: 1-290.
9. Larsson B, Tjalwe H. Studies on the mechanism of drug-binding to melanin. Biochem Pharmacol 1979; 28: 1181-87.
10. Stepien KB, WilczokT. Studies of the mechanism of chloroquine binding to synthetic dopa-melanin. Biochem Pharmacol 1982; 31: 3359-65.
11. Larsson B, Nilsson M, Tjalwe H. The tissue deposition of gentamicin in rats. Acta Pharmacol Toxicol 1981; 48: 269-78.
12. Lyden-Sokolowski A, Larsson B, Lindquist NG. Melanin affinity of manganese. Acta Pharmacol Toxicol 1984; 55: 133-8.
13. Larsson B, Lindquist NG, Johansson E, et al. Analysis of metals in skin melanin. Asbstract. 3rd Annual Meeting of the ESPCR, Amsterdam 1991, 62.
14. Danielsson BRG, Oskarsson A, Dencker L. Placental transfer and fetal distribution of lead in mice after treatment with dithiocarbamates. Arch Toxicol 1984; 55: 27-33.
15. Dencker L, Larsson B, Olander K, et al. False precursors of melanin as selective melanoma seekers. Br J Cancer 1979; 39: 449-52.
16. Palumbo A, dlschia M, Misuraca G, et al. Selective uptake of 2-thiouracil into melanin-producing systems depends on chemical binding to enzymatically generated dopaquinone. Biochim BiophysActa 1990; 1036: 221-7.
17. Lindquist NG. Accumulation of drugs on melanin. Acta Radiol 1973; (Suppl.325): 1-92.
18. Burns RP. Delayed onset of chloroquine retinopathy. New Engl J Med 1966; 275: 693-6.
19. Dencker L, Lindquist NG, Ullberg S. Mechanism of drug-induced chronic otic lesions. Role of drug accumulation on the melanin of the inner ear. Experientia 1973; 29: 1362-3.
20. Kordysh EA, Herishanu Y, Goldsmith JR. Chemical exposures and Parkinson's disease in residents of three Negev kibbutzim. Environ Res 1997; 73: 162-5.
21. Richardson MA, Craig TJ. The coexistence of parkinsonism-like symptoms and tardive dyskinesia. Am J Psychiatry 1982; 139: 341-3.
22. Gupta SK, Murthy RC, Chandra SV. Neuromelanin in manganese-exposed primates. Toxicol Lett 1980; 6: 17-20.
23. Faraldi F, Reyes MG, Alfieri E, et al. The aging substantia nigra: quantitative histologic study. Panminerva Med 1994; 36: 103-8.
24. Lindquist NG, Larsson B, Lyden-Sokolowski A. Neuromelanin and its possible protective and destructive properties. Pigment Cell Res 1987; 1: 133-6.
25. Chiueh CC, Markey SP, Burns RS, et al. N-methyl-4-phenyl-tetrahydropyridine, a parkinsonian syndrome causing agent in man and monkey, produces different effects in guinea pig and rat. Pharmacologist 1983; 25: 131.
26. Heikkila RE, Hess A, Duvoisin RC. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-tetrahydropyridine in mice. Science 1984; 224: 1451-3.
27. Barden H, Levin S. Histochemical observations on rodent brain melanin. Brain Res Bull 1983; 10: 847-51.
28. Merighi A, Peirone SM. Histochemical and ultrastructural features of neuronal pigment in some encephalic nuclei of ruminants. Exp Biol 1985; 44: 109-21.
29. Barden H. The intragranular location of carboxyl groups in neuromelanin and lipofuscin in human brain and in meningeal melanosomes in mouse brain. J Histochem Cytochem 1986; 34: 1271-9.
30. Cozzi B, Pellegrini M, Droghi A. Neuromelanin in the substantia nigra of adult horses. Anat Anz 1988; 166: 53-61.
31. Leblanc B, Jezequel S, DaviesT, et al. Binding of drugs to eye melanin is not predictive of ocular toxicity. Regul Toxicol Pharmacol 1998; 28: 124¬32.
32. Roskoski JR, Jaskunas SR. Chloroquine and primaquine inhibition of rat liver cell-free polynucleotide-dependent polypeptide synthesis. Biochem Pharmacol 1972; 21: 391-9.
33. Homewood CA, Warhurst DC, Peters W, et al. Lysosomes, pH, and the antimalarial action of chloroquine. Nature 1972; 235: 50-2.
34. Koh HK, Kliger BE, Lew RA. Sunlight and cutaneous malignant melanoma: Evidence for and against causation. Photochem Photobiol 1990; 51: 765-79.
35. Evans RD, Kopf AW, Lew RA, et al. Risk factors for the development of malignant melanoma. J Dermatol Surg Oncol 1988; 14: 393-408.
36. Austin DF, Reynolds P. Occupation and malignant melanoma of the skin. Recent Results Cane Res 1986; 102: 98-107.
37. Magnani C, Coggon D, Osmond C, et al. Occupation and five cancers: A case control study using death certificates. Br J Ind Med 1987; 44: 769¬76.
38. Roberto A, Larsson BS, Tjalve H. Uptake of 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene in melanin-containing tissues. Pharmacol Toxicol 1996; 79: 92-9.
39. Berkelhammer J, Oxenhandler RW, Hook RR, et al. Development of a new melanoma model in C57BL/6 mice. Cancer Res 1982; 42: 3157-63.
40. Creel D. Inappropriate use of albino animals as models in research. Pharmacol Biochem Behav 1980; 12: 969-70.

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