You are here

Home » Content

SEREBROVASKÜLER OLAY GEÇİREN HASTALARDA SERUM NİTRİT VE NİTRAT DÜZEYLERİ

Serum Nitrite And Nitrate Levels In Patients With Cerebrovascular Accident

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objectives: This study was conducted to determine serum levels of nitrite and nitrate in patients with cerebrovascular accident (CVA) and to assess whether there are correlations between serum NO end-product levels with some clinical and laboratory parameters. Material and Methods: Thirty-four patients with ischaemic CVA, thirty seven patients with hemorrhagic CVA admitted to the Emergency Department and Outpatient Clinic of Neurology of Turgut OzaO Medical Center together with thirty healthy age and sex matched volunteers were included into this study. Routine blood analyses and cerebral CT scans were taken on admission and after medical treatment. In addition, demographic parameters (age and gender) type of CVA (ischaemic or hemorrhagic), affected side of the body (right or left), severity of CVA (hemiparesis or hemiplegia), and the localization of the pathologic lesion in the CT scan were recorded. Six patients with hemorrhagic CVA who died during the study period were excluded from the analysis. Results: Statistical values were calculated as mean"standard error. There were no statistical significant differences in serum nitrite concentrations (10.9"0.4 —mol/L vs. 12.0"0.4 —mol/L, 10.3"0.3 —mol/L vs. 11.2"0.5 —mol/L, p>0.05) between the admission level and that after medical treatment in ischaemic and hemorrhagic patients. Similarly there were no statistically significant differences in serum nitrate concentration (24.4"3.3 —mol/L vs. 23.1"2.1 —mol/L, 36.1"6.1 —mol/L vs. 29.1"3.4 —mol/L, p>0.05) between ischaemic and hemorrhagic CVA patients. But, serum nitrite (1.7"0.1 —mol/L) and nitrate (18.4"0.9 —mol/L) levels in healthy volunteers were significantly lower than both of the patient groups (p<0.001). Although, there was no correlation between the clinical and laboratory findings with serum nitrite and nitrate levels in hemorrhagic patients (p>0.05), there was a positive correlation between the CVA severity and serum nitrite levels at the admission (r-0.384) and that after medical treatment (r-0.514) in patients with ischaemic type of CVA (p<0.05). Conclusion: We found that, there was a positive correlation between the severity of CVA and serum nitrite levels at admission and that after treatment in patients with ischaemic CVA. In addition, serum nitrite and nitrate levels were statistically higher in patient groups than healthy volunteers. Our findings suggest that, NO may contribute in pathogenesis of CVA. How this is achieved is not certain and needs further research.
Bookmark/Search this post with
Abstract (Original Language): 
Amaç: Serebrovasküler olay (SVO) geçiren hastaların serumlarında nitrik oksit (NO) son ürünleri olan nitrit ve nitrat düzeylerinin belirlenerek bazı klinik ve laboratuvar parametreleri ile ilişkisinin araştırılması. Materyal ve Metot: Hastanemiz Acil Servisine ve Nöroloji Polikliniklerine başvurup, SVO tanısı konmuş 34'ü iskemik, 37si hemorajik toplam 71 olgu ile yaş ve cinsiyetleri uyumlu çalışma hakkında bilgilendirilen 30 sağlıklı bireyden oluşan kontrol grubu çalışmaya dahil edildi SerebraO CT incelemeleri yanısıra uygulanan medikai tedaviden önce ve sonra (taburcu olurken) alınan kan örneklerinde serum nitrit ve nitrat düzeyleri tespit edildi Olguların demografik özellikleri (yaş ve cins), SVO'nun tipi (iskemik veya hemorajik), etkilenen vücut tarafı (sağ veya sol), klinik tablonun şiddeti (hemiparezi veya hemipleji) ve kranial CT'de Oezyonun bulunduğu bölge kaydedildi. Takip eden günlerde eks ile sonuçlanan 6 hemorajik SVO'iu olgu çalışmadan çıkarıldı. Oezyonun bulunduğu bölge kaydedildi. Takip eden günlerde eks ile sonuçlanan 6 hemorajik SVO'iu olgu çalışmadan çıkarıldı. Bulgular: İstatistiksel olarak elde edilen veriler ortalama değer+standart hata olarak hesaplandı. Tedaviden önce ve sonra serum seviyeleri karşılaştırıldığında, hem iskemik hem de hemorajik olgularda nitrit (10.9+0.4 —mol/L ve 12.0+0.4 —mol/L, 10.3+0.3 —mol/L ve 11.2+0.5 —mol/L) ve nitrat (24.4+3.3 —mol/L ve 23.1+2.1 —mol/L, 36.1+6.1 —mol/L ve 29.1+3.4 —mol/L) değerleri arasında istatistiksel olarak anlamlı fark saptanmadı (p>0.05). Bununla birlikte, kontrol grubunu oluşturan bireylerin serum nitrit (1.7+0.1 —mol/L) ve nitrat (18.4+0.9 —mol/L) düzeyleri hasta gruplarındaki olgulara göre daha düşük seviyelerde tespit edildi. İskemik ve hemorajik olgularda serum nitrit ve nitrat değerleri ile; SVO'nun tipi, etkilenen vücut tarafı ve CT'deki Oezyonun yeri arasında istatistiksel olarak anlamlı derecede bir iOişki saptanmazken (p>0.05), iskemik oOguOarda kOinik tabOonun şiddeti iOe hem tedavi öncesi (r-0.384) ve hem de tedavi sonrası (r-0.514) serum nitrit seviyeOeri arasında istatistikseO oOarak anOamOı iOişki saptandı (p<0.05). Buna iOave oOarak, hem iskemik hem de hemorajik SVO'iu olgularda tedavi öncesi ve sonrasındaki serum nitrit ve nitrat düzeylerinin, kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksek oldukları tespit edildi (p<0.001). Sonuç: SVO'iu iskemik olgularda klinik tablonun şiddeti ile serum nitrit seviyeleri arasında pozitif korelasyonun olması ve sağlıklı bireylerle karşılaştırıldığında SVO'iu olgularda serum nitrit ve nitrat düzeylerinin yüksek bulunması, NO'in SVO'nun patogenezinde rolü olabileceğini desteklemektedir. Sınırlı sayıda olgularda elde edilen bu verilerin doğrulanması için ileri çalışmalara ihtiyaç duyulmaktadır.
FULL TEXT (PDF): 
PDF icon arastirmax-serebrovaskuler-olay-geciren-hastalarda-serum-nitrit-nitrat-duzeyleri.pdf
  • 3
224-228
  • Turkish

REFERENCES

References: 

1. Castillo J, Rama R, Davalos A. Nitric oxide-related brain damage in acute ischemic stroke Stroke 2000; 31: 852-7.
2. Gursoy-Ozdemir Y, Bolay H, Saribas O, Dalkara T. Role of endothelial
nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia Stroke 2000; 31: 1974-80.
3. Nemoto EM. A complex role for nitric oxide in ischemic stroke. Crit Care
Med 2000; 28: 280-1.
4. Faraci FM, Brian JE. Nitric oxide and the cerebral circulation. Stroke 1994; 25: 692-703.
5. Samdani AF, Dawson TM, Dawson VL. Nitric oxide synthase in models
of focal ischemia. Stroke 1997; 28: 1283-8.
6. Stichtenoth DO, Frolich JC. Nitric oxide and inflammatory joint diseases.
Br J Rheumatol1998; 37: 246-57.
7. Zhang J, Benveniste H, Klitzman B, Piantadosi CA Nitric oxide synthase
inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion Stroke 1995; 26: 298-304.
8. Fassbender K, Fatar M, Ragoschke A, Picard M, Bertsch T, Kuehl S, Hennerici M. Subacute but not acute generation of nitric oxide in focal cerebral ischemia. Stroke 2000; 31: 2208-11.
9. Iadecola C, Zhang F, Casey R, Clark HB, Ross ME. Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral
ischemia. Stroke 1996; 27: 1373-80.
10. Wei HM, Chi OZ, Liu X, Sinha AK, Weiss HR. Nitric oxide synthase inhibition alters cerebral blood flow and oxygen balance in focal cerebral ischemia in rats. Stroke 1994; 25: 445-9.
11. Huang Z, Huang PL, Panahian N, Dalkara T , Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 1994; 265: 1883-5.
12. Snyder SH, Bredt DS. Nitric oxide as a neuronal messenger. Trends Pharmacol Sci 1991; 12: 125-8.
13. Chi OZ, Wei HM, Sinha AK, Weiss HR. Effects of inhibition of nitric oxde synthase on blood-brain barrier transport in focal cerebral ischemia. Pharmacology 1994; 48: 367-73.
14. O'Mahony D, Kendall MJ. Nitric oxide in acute ischaemic stroke: a target for neuroprotection. J Neurol Neurosurg Psychiatry1999; 67: 1-3.

Thank you for copying data from http://www.arastirmax.com