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Helicobacter Pylori Eradikasyon u ve Ülser iyileşmesinde Ranitidin Bizmut Sitrat ve Klaritromisin Kombinasyonunun Etkinliği

Efficacy of The Ranitidine Bismuth Citrate And Chlaritromycin Combination For Ulcer Healing And Helicobacter Pylori Eradication

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Helicobacter pylori (Hp) infection is an infectious disease that can cause various gastrointestinal disorders such as gastrit, peptic ulcus and MALTOMA. These disorders and related complications can be prevented by the eradication of Hp. In this study we aimed to investigate the effectiveness of Ranitidine bismuth citrate and clarithromycine combination which have been in use against this infection in our country for three years. 45 patient ( 32 male, 13 female), mean age 38 (20-60) who were diagnosed as having gastric or duodenal ulcus by the oesophagogastroduodenoscopy (OGD) and the detection of Hp in their biopsies were included in the study. Ranitidine bismuth citrate 2x400 mg for one month + Clarithromycin 2x500 mg were given to the patients for one week. OGD was performed in patients on day 15 and day 45 and biopsies were taken again. Hp negatives in repeated biopsies were considered as "eradication". Eleven of the 45 patients were excluded in the study, since they did not attend the control, their OGD and subsequent biopsies on day 15 could not be conducted. The eradication rates of the cases on day 15 and 45 days were 85.2% (29/34) and 91.1% (31/34) respectively. The ulcus healing rates were 88.2% (30/34), 94.1% (32/34) respectively. While there was no complain to cause the withdrawal of therapy, the most common side-effects seen were tastelessness and mild abdominal pain. As a result ıt was found that one week Ranitidine bismuth citrate therapy in the Hp eradication and ulcus healing was efficacious and comparable with the other triple combination therapies.
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Abstract (Original Language): 
Helicobacter Pylori (Hp) infeksiyon u gastrit, peptik ülser, MALTOMA gibi çeşitli gastrointestinal rahatsızlıklara yol açan bir infeksiyon hastalığıdır. Hp eradikasyonu ile bahsedilen gastrointestinal problemler ve bunlara bağlı komplikasyonlar önlenebilmektedir. Biz Hp eradikasyonu için son yıllarda ülkemizde de kullanılmaya başlanan Ranitidine-Bizmut Sitrat ve Klaritromisin kombinasyonunun etkinliğini araştırdık. Endoskopilerinde gastrik yada duodenal ülser tesbit edilen ve biyopsilerinde Hp (+) bulunan, yaş ortalaması 38 (20-60) olan 32 erkek ve 13 kadından oluşan 45 kişi çalışmaya alındı. Olgulara 1 ay süre ile Ranitidine- Bizmut Sitrat 2x400 mg + 1 hafta süre ile Klaritromisin 2x500 mg verildi. Olgulara 15, 45. günlerde endoskopi yapılarak biyopsileri alındı. Tekrarlanan biyopsilerinde Hp (-) olanlarda eradikasyon olduğu kabul edildi. Çalışmaya alınan 45 olgudan 11 tanesi kontrole gelemediği için 15. günde endoskopi ve biyopsileri yapılamadı ve bu olgular çalışma dışında tutuldu. Olguların 15, 45 günlerdeki Hp eradikasyon oranları sırası ile %85.2 (29/34), % 91.1 (31/34) idi. Olgulardaki ülser iyileşme oranları ise sırası ile %88.2(30/34), % 94.1 (32/34) idi. Hiç bir olguda tedavinin kesilmesini gerektiren bir yan etki oluşmazken en sık görülen yan etki tat değişikliği ve hafif karın ağrısı idi. Sonuç olarak Hp eradikasyonu ve ülser iyileşmesinde bir haftalık Ranitidin Bizmut Sitrat tedavisi diğer 3'lü kombinasyon tedavileri ile kıyaslanabilecek oranlarda etkin bulunmuştur.
FULL TEXT (PDF): 
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  • 3
169-173
  • Turkish

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