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Konjenital VSD'li Çocuklarda QT ve QTc Dispersiyon Değerleri

The Values Of QT And QTc Dispersion In Children With Congenital Ventricular Septal Defect

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The QT interval dispersion has long been known to be a marker of dispersion of ventricular repolarisation or electrical instability. Additionally, it has previously been shown that congenital ventricular septal defects (VSD) occasionally induce a QRS axis shift. There is no knowledge about QT and QTc dispersion indicating inhomogenous myocardial repolarization in the patients with VSD. In this study, we examined the values of dispersion of ventricular repolarization in the patients with VSD. We examined 21 patients (mean age;6±2 years, 9M, 12F) with VSD and 26 age matched healthy subjects as the control group (mean age;9± 3 years, 14M, 12F). We found QTd and QTc-d intervals of 54.2 ± 12.2 ms, 72,4 ± 9.2 ms in the patients withVSD, where the values for control group were 45.1 ± 11.3ms and 61.5 ± 6.7ms respectively (for all, P< 0.05). Important increase in QT and QTc dispersion indicating inhomogenous myocardial repolarization were noted in patients with VSD. In conclusion the data of this study suggest that the patients with VSD appear to have repolarization abnormalities, reflected by an increase in QT and QTc dispersion. This finding may be important in the explanation of ventricular repolarization abnormalities in patients with VSD.
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Abstract (Original Language): 
QT interval dispersiyonunun , ventriküler repolarizasyon dispersiyonu veya elektriksel instabilitenin bir göstergesi olduğu uzun zamandır bilinmektedir. Ayrıca, konjenital ventriküler septal defektlerin (VSD) bazen QRS aks değişikliğine neden olduğu daha önceden belirlenmiştir. VSD'si olan hastalarda ventriküler repolarizasyon heterojenitesini gösteren QT ve QTc dispersiyonu hakkında hiçbir bilgi yoktur. Bu çalışmada, konjenital VSD olanlar çocuklarda ventriküler repolarizasyon dispersiyon değerlerini araştırdık. Çalışma VSD'si olan 21 hastayı (ortalama yaş;6± 2yıl, 12 E, 9 K) ve kontrol grubu olarak 26 sağlıklı çocuğu (ortalama yaş;9± 3yıl, 14 E, 12 K) içeriyordu. VSD'si olan hastalarda QT ve QTc dispersiyon değerleri sırasıyla 54.2+/-12.2, 72.48+/- 9.2 ms iken kontrol grubunda bu değerler sırasıyla 45.1+/- 11.3ms, 61.5+/-6.7 ms olduğunu bulduk (tümü için p < 0.05). VSD'si olan hastalarda homojen olmayan miyokardiyal repolarizasyonu gösteren QT ve QTc dispersiyon değerlerinde önemli artışlar olduğu kaydedildi. Sonuç olarak, bu çalışma konjenital VSD'i olan hastaların QT ve QTc dispersiyonunun artması olarak yansıyan repolarizasyon anormalliklerine sahip olduğunu ortaya çıkarmıştır. QT ve QTc dispersiyonunun artması VSD''i olan hastalarda ventriküler repolarizasyon anormalliklerinin açıklanmasında önemli olabilir.
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  • 4
241-243
  • Turkish

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