You are here

ANTI INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF NYMPHAEA ALBA FLOWER IN SWISS ALBINO MICE

Journal Name:

Publication Year:

DOI: 
10.5958/j.2319-5886.2.3.082
Abstract (2. Language): 
Inflammation plays an important role in various diseases with high prevalence within populations such as rheumatoid arthritis, atherosclerosis and asthma. The aim of the present context to investigate the anti inflammatory activity of extract of Nymphaea Alba flower (NAF) in Swiss Albino mice. The anti inflammatory activity was test using acute inflammatory models like acetic acid-induced vascular permeability chronic models like; cotton-pellet induced granuloma. Oral administration of ethanolic extract of Nymphaea Alba flower at the doses of 100mg/kg and 200mg/kg of body weight in mice.Diclofenac sodium used as standard drug Exhibited dose dependent and significant antiinflammatory activity in acute (acetic acid-induced vascular permeability, p< 0.001) and chronic (cotton pellet granuloma < 0.001). But at the dose of 200mg/kg of extract shown high significant than 100mg/kg. Hence, the present investigation established ethanolic extract of Nymphaea Alba flower has anti-inflammatory activity.
FULL TEXT (PDF): 
474-478

REFERENCES

References: 

1. Oyedapo OA, Adewunmi CO, Iwalewa EO,
Makanju VO. Analgesic, antioxidant and
anti-inflammatory related activities of 21-
hydroxy-2,41-dimethoxychalcone and 4-
hydroxychalcone in mice. Journal of
Biological Sciences, 2008;8(1):131–36
2. Anilkumar M. Ethnomedicinal plants as antiinflammatory
and analgesic agents in
Ethnomedicine: A Source of Complementary
Therapeutics, Research Signpost, India,
2010;267-91
3. Conforti F, Sosa S, Marrelli M. The
protective ability of Mediterranean dietary
478
Jacob et al., Int J Med Res Health Sci. 2013;2(3):474-478
plants against the oxidative damage: the role
of radical oxygen species in inflammation
and the polyphenol, flavonoid and sterol
contents. Food Chemistry, 2009;112(3):587–
94
4. IMS Health, IMS National Sales Perspectives
TM, 2005
5. Robert A. Antisecretory, antiulcer,
cytoprotective and diarrheogenic properties
of prostaglandins. Advances in Prostaglandin
and Thromboxane Research.1976;2:507–20
6. Peskar BM. On the synthesis of
prostaglandins by human gastric mucosa and
its modification by drugs. Biochimica et
Biophysica Acta.1977;487(2):307–14, 1977
7. Tapiero H, Nguyen Ba G, Couvreur P, Tew
KD. Polyunsaturated fatty acids (PUFA) and
eicosanoids in human health and
pathologies,” Biomedicine and
Pharmacotherapy.2002;56(5): 215–22.
8. Dharmasiri MG, Jayakody JRAC, Galhena
G, Liyanage SSP, Ratnasooriya WD. Antiinflammatory
and analgesic activities of
mature fresh leaves of Vitex negundo,”
Journal of Ethnopharmacology.
2003;87(2):199–206
9. Kumara N. Identification of strategies to
improve research on medicinal plants used in
Sri Lanka,” in Proceedings of the WHO
Symposium, pp. 12–14, University of
Ruhuna, Galle, Sri Lanka, 2001
10. Eliana R, Ricardo T, Jose C, Galduroz F,
Giuseppina N. Plants with possible anxiolytic
and/or hypnotic effects indicated by three
brazilian cultures - indians, afrobrazilians,
and river- wellers. Studies in Natural
Products Chemistry. Vol. 35. Brazil:
Elsevier; 2008. p. 549-95
11. Handa SS, Sharma A. Hepatoprotective
activity of andrographolide from
Andrographis paniculata against
carbontetrachloride. Indian J Med Res. 1990;
92:276-83
12. Whittle BA. The use of changes in capillary
permeability in determination of glutamic
oxaloacetate and glutamic pyruvic transa
minase. Am J Clin Pathol,1957;28: 96.
13. Winter CA, Hisley EA, Nuss GW.
Carageenan induced edema in hind paw of
rats as an assay of anti-inflammatory drugs.
Proc Soc Exp Biol Med. 1962;111:544–47
14. Ojewole AOJ. Evaluation of antiinflammatory
property of sclerocarya birrea
(A.Rich) Hochst (Family: Anacardiaceae)
stem bark extracts in rats. J Ethnopharmacol.
2003;85:217-220.
15. Winter CA, Porter CC. Effect of alterations
in the side chain upon anti-inflammatory and
liver glycogen activities of hydrocortisone
esters. J. Am. Pharm. Assoc. Sci.
Educ.1957;46: 515-19
16. Adnaik RS, Pai PT, Sapakal VD, Naikwade
NS Magdum CS. Anxiolytic activity of Vitex
Negundo Linn. In experimental models of
anxiety in mice. Int J Green Pharm
2009;3:243-47
17. Robin D. Nymphaea odorata: White pond
lily. Medical Herbalism. Materia Medica
pharm 2001;11:231-33
18. Vergeera LH, Vander VG. Phenolic content
of daylight-exposed and shaded floating
leaves of water lilies (Nymphaeaceae) in
relation to infection by fungi. Oecologia
1997;112:481-84
19. James AD. Duke's hand book of medicinal
plants of the bible. USA: Taylor and Francis
group.2008.p.302-5
20. Naghma K, Sarwat S. Anticarcinogenic effect
of Nymphaea alba against oxidative damage
and hyperproliferative response and renal
carcinogenis in Wistar rats. Mol Cell
Biochem.2005;271:1-11

Thank you for copying data from http://www.arastirmax.com