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DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE AND DESLORATADINE HYDROCHLORIDE IN COMBINED TABLET DOSAGE FORM

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

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Abstract (2. Language): 
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first order derivative spectrophotometric method for the simultaneous determination of Ambroxol Hydrochloride and Desloratadine Hydrochloride in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra were obtained in 0.1 N Hydrochloric acid and the determinations were made at 256 nm (ZCP of Desloratadine Hydrochloride) for Ambroxol Hydrochloride and 308 nm (ZCP of Ambroxol Hydrochloride) for Desloratadine Hydrochloride. The linearity was obtained in the concentration range of 10 - 80 [ig/ml for Ambroxol Hydrochloride and 5 - 40 [ig/ml for Desloratadine Hydrochloride. The mean % recovery was 98.84 - 100.05% and 99.49 - 101.62% for Ambroxol Hydrochloride and Desloratadine Hydrochloride, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of Ambroxol Hydrochloride and Desloratadine Hydrochloride in pharmaceutical combined tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
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  • English