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DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFPODOXIME PROXETIL AND DICLOXACILLIN SODIUM IN COMBINED TABLET DOSAGE FORM

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first order derivative spectrophotometric method for the simultaneous determination of Dicloxacillin sodium and Cefpodoxime Proxetile in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra was obtained in methanol and the determinations were made at 237.2nm (ZCP of Cefpodoxime proxetil) for dicloxacillin sodium and 307.8 nm (ZCP of Dicloxacillin sodium) for Cefpodoximeproxetil. The linearity was obtained in the concentration range of 10¬90 ug/ml for cefpodoxime proxetil and 50-200 ug/ml for Dicloxacillin sodium. The mean recovery was 98.71-102.77% and 98.69-99.62% for cefpodoxime proxetil and dicloxacillin sodium, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of cefpodoxime proxetil and dicloxacillin sodium in pharmaceutical combined tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
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  • English

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