EXPLORATION OF DIFFERENT POLYMERS AND OPTIMIZATION OF CONCENTRATION OF PLASTICIZER IN THE FORMULATION OF ORAL FAST DISSOLVING STRIPS

In the recent years, many of the pharmaceutical groups are focusing their research on rapid dissolving technology. Amongst the rapid drug releasing products, Oral film technology is gaining much attention. The main advantage of this technology is the administration to pediatric and geriatric patient population where the difficulty of swallowing larger oral dosage forms is eliminated. The Aim behind this study was to explore the film forming properties of various film formers used in oral film technology and optimization of concentration of plasticizer for good tensile strength and also the folding endurance. The films were prepared by solvent casting method. Prepared strips were evaluated for film forming capacity, visual appearance, disintegration time, tensile strength and their folding endurance. The different polymers used for formulation of film were HPMC E5, HPMC K100, PVA, PVP, Gelatin, HPMC in combination with Xanthan gum and plasticizer used was polyethylene glycol (PEG 400) in different proportions (0.1, 0.2, and 0.3). Very transparent visual appearance, Best film forming capacity and least disintegration time of HPMC E5 and HPMC k100 polymers were observed in the study. So HPMC E5 is the best film forming agent among all film forming polymers with PEG400 in proportion of 0.2ml for good tensile strength and folding endurance.