You are here

Home » Content

METHOD DEVLOPMENT AND VALIDATION OF CEFIXIME AND MOXIFLOXACIN IN PHARMACEUTICAL DOSAGE FORM BY UV SPECTROPHOTOMETRIC METHOD

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author NameUniversity of Author
Abstract (2. Language): 
Versatile, accurate, precise and economic method for determination of cefixime and moxifloxacin in fixed dose combination mixture was developed. The absorbance values at 286.0 nm and 295.0 nm and 279nm (isoabsorptive point) were used for the estimation of cefixime and moxifloxacin, respectively without mutual interference. This method obeyed Beer's law in the concentration range of 2-18 |ig /ml for cefixime and 2-12 |ig /ml for moxifloxacin. The results of analysis have been validated statistically for linearity, accuracy and precision, LOD and LOQ of the proposed method.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-method-devlopment-and-validation-cefixime-and-moxifloxacin-pharmaceutical-dosage-form-uv-spectrophotometric-method.pdf
  • 2
  • English

REFERENCES

References: 

1.
Unite
d state pharmacopoeia, 30th edition, Rockville; USP convention, Inc; 2007:1654¬6.
2.
Britis
h Pharmacopoeia. Department of Health. London: HMSO Publication; 2008: 1140.
3.
Becket
t AH and Stenlake JB: UV-visible Spectrophotometry Practical Pharmaceutical Chemistry, C.B.S.
Publishers, Delhi, 4th edition 2001, Part-II: 285-297.
4.
Kennet
h A Connors: Text book of pharmaceutical analysis. 3rd ed. NY Wiley interscience 2002: 353.
5. Barar FSK: Essentials of Pharmacotherapeutics. S. Chand & Company Ltd. Reprint 2005; 417.
6. Brunton,
LL
, Lazo JS and Parker KL: Goodman and Gil man's The Pharmacological Basis of Therapeutics. 11th edition. The MC Grew Hill companies Inc; 2005: 1105-1106, 1206, 1211, 1183.
7. Heinz L, Kluse M, Albert Z and Detlef B. Colour atlas of pharmacology. 2nd edition. Thieme publishers; 2005: 270, 274.
8. http://www.medlineindia.com/cefixime retrieved on 25/12/2009
9. Oliphant CM and Green GM: Quinolones: A Comprehensive review. Am Fam Physician February 2002; 65: 455-64.
10. Moffat AC, Osselton MD and Widdop
B: Clarke's Analysis of Drugs and Poisons.
3rd edition. Pharmaceutical Press; 2004; 2:
1172-3.
11. Available online at http://en.wikipedia.org/wiki/Moxifloxacin
12. Available online at http://www.drugbank.ca/drugs/DB00218.
13. Shah PB and Pundarikakshudu K. Spectrophotometric, difference spectroscopic and high performance liquid chromatographic methods for the determination of Cefixime in pharmaceutical formulations. American Journal of analytical chemistry 2006; 89:
987-94.
14. Nanda RK, Gaikwad J and Prakash A: Estimation of Cefixime and Ornidazole in its pharmaceutical dosage form by spectrophotometric method. Journal of Pharmacy Research 2009; 2: 1264-66.15. Nanda RK, Gaikwad J and Prakash A: Simultaneous spectrophotometric estimation of Cefixime and Ornidazole in tablet dosage form. International Journal of Pharmatech Research 2009; 1: 488-91.
16. Misra M, Misra AK, Zope P, Panpalia GM and Dorle AK: Simple and validated Uv-spectroscopy method for estimation of Moxifloxacin in bulk and formulation. Journal of Global Pharma Technology: 5-10.
17.
Dines
h MD, Atul AS and Sanjay JS: Quantitative determination of Moxifloxacin. HCl in bulk and ophthalmic solution by UV-spectrophotometry and first order derivative using area under curve. Der Pharmacia Lettre, 2011, 3: 453-456.
Ava

Thank you for copying data from http://www.arastirmax.com