You are here

Home » Content

SOLUBILITY IMPROVEMENT OF CEFPODOXIME PROXETIL BY INCLUSION IN 2-HYDROXYPROPYL-ß-CYCLODEXTRIN

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The aim of this study was to enhance the solubility and bioavailability of cefpodoxime proxetil (CFP) through complexation with 2-hydroxypropyl-P-cyclodextrin (HP- P -CD). CFP is a poorly water soluble antibiotic drug. Reportedly, it has slow, erratic, and complete absorption after oral administration. This present report d escribes the study of the phase solubility diagram, preparation of the inclusion complex, In-Vitro dissolution study of optimized ratio. An AL-type phase solubility diagram indicated a 1: 1 complex of CFP-HP-P-CD with the constant of complex formation of 188.35 M-1 at 37°C. The complex formation was confirmed by DSC, IR. The extent of absorption of the complex was determined in rats and was compared with that of pure drug. The pure CFP shows 9.7 % Corrected cumulative Drug release (CCDR) in hr while kneded drug co mplex with HP-P-CD shows 53.06 %CCDR. The solubility and dissolution rates of CFP were significantly increased by Hydroxypropyl cyclodextrin complexes.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-solubility-improvement-cefpodoxime-proxetil-inclusion-2-hydroxypropyl-ss-cyclodextrin.pdf
  • 2
  • English

REFERENCES

References: 

1.
Hamad
a Y, Nambun N and Nagai T: Interactions of and P-cyclodextrins with several non-steroidal anti inflammatory drugs in aqueous solution. Chem. Pharm. Bull.1975; 23: 1205-1211.
2.
Glomo
t F, Benkerrour L, Duchene D and Poelman MC: Improvement in availability and stability of a dermocorticoid by inclusion in P-cyclodextrin. In. J. Pharm. 1988; 46: 49-55.
3.
Youse
f Javadzadeh: Liquid solid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine), International Journal of Pharmaceutics-2007.
4.
Uekam
a K, Narisawa S, Hiryama, F. and Otagiri M, Improvement of dissolution and absorption characteristics of benzodiazepines by cyclodextrin complexation. Int. J. Pharm. 1983; 16: 327¬338.
5. Nambu N, Shimoda M, Takahashi Y, Ueda H and Nagai T: Bioavailability of powdered inclusion compounds of non steroidal anti inflammatory drugs with P-
cyclodextrin in rabbits and dogs. Chem. Pharm. Bull. 1978; 26: 2992- 2996
6.
India
n Pharmacopoeia, Volume -III, the Indian Pharmacopoeia Commission, Ghaziabad, Govt. of India, Ministry of Health and Family Welfare. 2007: 232-233
7.
Unite
d state pharmacopoeia 30- National formulary 25, United state pharmacopoeial convention.
8.
Li-Pin
g Ruan: Improving the solubility of ampelopsis by solid dispersions and inclusion complexes, Journal of Pharmaceutical and Biomedical Analysis-
2005.
9. R. Nair: Influence of polyethylene glycol and povidone on the polymorphic transformation and solubility of carbamazepine, International Journal of Pharmaceutics-2002.
10.
Higuchi
, T. and Connors, K.A., Phase solubility techniques. In Reilley, C.N. (Ed.), Advances in Analytical Chemistry and Instrumentation, Interscience, New York,
1965:132.11.
KP
R Chowdary: Effect of polyvinyl pyrrolidone on complexation and dissolution rate of beta and hydroxy propyl beta cyclodextrin of celecoxib. IJPS 2010.
12.
Taru
n K. Patel et al. Comparative study on effect of Natural and Synthetic super Disintegrates in the formulation of Carbamazepine Fast Dissolving Tablets, JPSBR-2011.
13.
Sarasij
a Suresh: Effect of beta cyclodextrin complexation on the solubility and dissolution rate of carbamazepine tablet, ,International Journal of Pharmaceutical science 2010.
14.
Rawat
S
and Jain SK:
Rofecoxib
—
cyclodextrin inclusion complex for solubility enhancement. Pharmazie.
15. Rajeswari Challa: Cyclodextrins in
Dru
g Delivery: An Updated Review Submitted: June 11, 2004; Accepted: January 26, 2005; Published: October 14,
2005.
16.
CR
Palem
, S Patel and VB Pokharkar Solubility and Stability Enhancement of Atorvastatin by Cyclodextrin Complexation PDA J Pharm Sci and Tech 2009; 63: 17¬225.
17. Rajewski RA, Stella VJ. Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery. J Pharm Sci. 1996; 85: 1142-1168.
18. Castillo JA, Canales JP, Garcia JJ, Lastres JL, Bolas F, Torrado JJ. Preparation and characterization of albendazole beta-cyclodextrin complexes. Drug Dev Ind Pharm. 1999; 25: 1241-1248.
19. Diaz D, Escobar Llanos CM, Bernad MJB. Study of the binding in an aqueous medium of inclusion complexes of several cyclodextrins involving fenoprofen calcium.
Drug Dev Ind Pharm. 1999; 25: 107-110.
20. Arias-Blanco MJA, Moyano JR, Martinez JIP, Gines JM. Study of inclusion complex of gliclazide in a-cyclodextrin. J
Pharm Biomed Anal. 1998; 18: 275-279.
21. K D Tripathi "Essentials of Medical Pharmacology" Edition 6th, Published by Jaypee Brothers Medical Publishers.
22. HP Rang, M. Maureen Dale, Rang and Dale's pharmacology, Edition 6, illustrated, Published by Churchill Livingstone, 2007.
23. "Drug information handbook" by LEXI-COMP'S Clinical Reference library, 8th
Edition 2000-2001.

Thank you for copying data from http://www.arastirmax.com