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DEVELOPMENT AND IN VITRO EVALUATION OF TABLET IN CAPSULE DRUG DELIVERY SYSTEM FOR SIMULTANEOUS ADMINISTRATION OF TWO ANTI-PLATELET DRUGS

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Large number of elderly population suffers from heart stroke and secondary symptoms associ ated with it. To treat this condition, a novel tablet in capsule approach was developed wherein the combi nation of two antiplateletdrugs was used. Clopidogrel bisulphate was used as an immediate release blend incorporated in hard gelatin capsule which shows quicker onset of action while enteric coated aspirin tablet incorporated in capsule shows pulsatile release after predetermined lag time of about 4 h. The immediate release blend completely dissolved in 0.1 N HCl (1.2 pH) within 120 min. The enteric coatin g polymers, Eudragit L100 and Eudragit S 100 having pH dependent solubility, were used for coatin g of aspirin tablet for achieving desired lag time before rapid and complete drug release. The lag time and drug release depends upon coating level of pH dependent polymers.
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  • English

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