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KINETICS OF OXIDATION OF PHENYLEPHRINE BY CHLORAMINE-B IN HClO4 MEDIUM - A MECHANISTIC APPROACH

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Abstract (2. Language): 
Kinetics of oxidation of phenylephrine(PHE) by N-chlorobenzene sulphonamide or chloramine-B (CAB) has been carried out in HClO4 medium at 303K. The reaction exhibits first order dependence of rate on chloramine-B and fractional order dependence of rate on both phenylephrine and [HClO4]. The addition of halide ions and reduction product of CAB have no significant effect on the reaction rate. There is a negative effect of dielectric constant of the medium. The reaction rate remained unchanged with the variation of ionic strength of the medium indicating that non ionic species are involved in the rate determining step. The reaction fails to initiate the polymerization of acrylamide. Activation parameters have been computed from the Arrhenius plots. Michaelis-Menten type of kinetics has been proposed. The reaction stoichiometry and oxidation products were identified. The proposed mechanism and derived rate equation are consistent with the observed kinetic data.