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AN IMMUNOHISTOCHEMICAL STUDY OF THE SYNCYTIAL KNOTS IN THE PREECLAMPTIC PLACENTAS

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The successful pregnancy outcome is well coordinated with the perfect placentation that requires normal trophoblastic functioning. The syncytial knots are the end products of trophoblastic life cycle which includes continuous process of apoptosis and these knots may reflect the rate of apoptosis in placental tissue. Preeclampsia or pregnancy induced hypertension has been linked with altered trophoblastic apoptosis. Our study aims for calculating and comparing the trophoblastic and syncytial knot apoptotic rates between normal and preeclamptic placentas by using M30 immunostaining. The results of our study shows increased rate of trophoblastic apoptosis and syncytial knots formation in preecamptic placentas as compared to normal placentas. The syncytial knots were higher in peripheral regions of placentas. There was a positive correlation between trophoblastic apoptotic index and number of syncytial knots in the preeclamptic placenta.
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  • English

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Available Online At www.ijprbs.com
Research Article
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ISSN: 2277-8713
IJPRBS
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