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DEVELOPMENT AND EVALUATION OF TROCHES CONTAINING CHLORHEXIDINE HCL AND TRIAMCINOLONE FOR TREATMENT OF DENTAL PLAQUE, GINGIVITIS AND MOUTH ULCERS

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The mouth of human body provides non (teeth) for natural microbial colonization. This can the accumulation of large masses of bacteria and their products at stagnant sites. Dental plaque and gingivitis are some of this type of conditions, which can develop due to microbial accumulation on teeth. And mouth ulcers are small, painful sores on the inside lining of the mouth. Chlorhexidine is widely used antimicrobial drug in treatment of dental plaque and gingivitis and triamcinolone is used as anti ulcerative as well as anti-inflammatory. A troche is a lozenge designed to deliver medications directly to the mucus membranes of the mouth by dissolving slowly when placed between the tongue and gums. Validated HPLC method was developed for quantitative estimation of Chlorhexidine HCl and Triamcinolone in dosage forms. Optimized mobile phase for these two drugs was 2.0 g of sodium octane sulphonate in a mixture of 120 ml of glacial acetic acid, 270 ml of water and 730 ml of methanol, and retention time was found as 9.8 and 4.2 minutes respectively for Chlorhexidine HCl and Triamcinolone.
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  • 5
211-237
  • English

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REFERENCES
Research Article ISSN: 2277-8713
Manisha Patel, IJPRBS, 2012; Volume 1(5): 211-237 IJPRBS
Available Online At www.ijprbs.com
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