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DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF CEFIXIME TRIHYDRATE AND LEVOFLOXACIN HEMIHYDRATE IN THEIR COMBINED TABLET DOSAGE FORM

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

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Abstract (2. Language): 
Two simple, accurate, precise and economical spectrophotometry methods have been developed for the estimation of Cefixime trihydrate (CEF) and Levofloxacin hemihydrates (LEVO) simultaneously in tablet dosage form. Simultaneous method (Method 1) and Absorbance Ratio (Q-Absorbance) method (Method 2) were used. The wavelength ranges 240.27 nm and 296.28 nm in Simultaneous method were selected to determine Cefixime trihydrate (CEF) and Levofloxacin hemihydrate (LEVO), respectively and wavelength ranges 289.39 nm (iso-absorptive point) and 240.27 nm (Amax of Cefixime trihydrate) were selected for Absorbance ratio (Q-Absorbance) method. Beer's law is obeyed in the concentration ranges of 3-15 ug/ml and 3-15 ug/ml for Cefixime trihydrate(CEF) and Levofloxacin hemihydrate(LEVO) for Simultaneous method as well as Absorbance ratio method. The % assay for commercial formulation was found to be in the range 99.92% - 100.07% for Simultaneous method and 99.85-100.04 % for Absorbance Ratio by the proposed methods. Recovery was found in the range of 98.33-101.25% for Cefixime trihydrate and 98.66-101 % for Levofloxacin hemihydrate by Simultaneous spectroscopic method and 98.33-100.75 % for Cefixime trihydrate and 98.66 -99% for Levofloxacin hemihydrate by Absorbance ratio method for both the Formulations.
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  • 5
502-515
  • English