Journal Name:
- The International Journal of Pharmaceutical Research and Bio-Science
| Author Name |
|---|
Abstract (2. Language):
Ranitidine hydrochloride (RNH) is a H2-receptor antagonist,
widely used in short term treatment of duodenal ulcer and
in the management of hypersecretory conditions
methods have been reported for the determination of
ranitidine in bulk, pharmaceutical dosage
biological fluids. This method shows poor sensitivity and/or
narrow range of linear response, time consuming. Here we
have developed a new method by simple diazodisation, a
Chromogenic agent reacts with NO2 group of ranitidine
hydrochloride and gives spectrophotometric reaction that
produce orange colour which gives absorption maxima at
504nm and validation shows a linear response from 100
500 mg/ml and correlation coefficient of 0.998.The method
was accurate, robust, simple and economic.
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FULL TEXT (PDF):
- 5
178-183