Journal Name:
- The International Journal of Pharmaceutical Research and Bio-Science
| Author Name | University of Author |
|---|---|
Abstract (2. Language):
Pharmaceutical chemistry began in 16th century and gave birth to Medicinal chemistry in the second half of the 17th century. Many important biochemical compounds and drugs of natural origin contain heterocyclic ring structures. Among these e.g. Carbohydrates, essential amino acids, vitamins, alkaloids, glycosides etc. the presence of heterocyclic structures in such diverse types of compounds is strongly indicative of the diverse types of the pharmacological activity. Diversity of biological response profile has attracted considerable interest of several researchers across the globe to explore this skeleton for its assorted therapeutic significance. By using different synthetic methods new benzimidazole derivatives were synthesized and further Melting points were determined by using Precision melting point apparatus in open capillaries and are uncorrected. The purity of the compounds was checked by TLC on silica gel G plates using n-Hexane, ethyl acetate (1:3) and methanol: chloroform (1:9) solvent system. The synthesized benzimidazole derivatives were characterized by IR, 1H NMR spectral analysis. Benzimidazole is a lead nucleus for future developments to get effective compounds.
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FULL TEXT (PDF):
- 5
398-405