You are here

Home » Content

UTILITY OF PAP SMEAR STUDY IN THE DIAGNOSIS OF VARIOUS NEOPLASTIC AND NON NEOPLASTIC LESIONS OF CERVIX.

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
BACKGROUND: Cervical cancer is one of the leading causes of death in Indian women. Pap smears are commonly used as cytological screening test for successful eradication of precancerous lesions, which has made it a routine procedure worldwide. Pap smears have been evaluated as a diagnostic test even in few non neoplastic conditions of cervix. OBJECTIVES: The study was conducted to explore various lesions of uterine cervix to find out target age group in which screening efforts can be concentrated for early detection as well as reduction of the incidence of cervical cancer and also to diagnose benign and inflammatory lesions to reduce the morbidity. STUDY DESIGN: Patients in the age group 18-65 years with various complaints were screened during August 2011 to August 2012. Total 221 patients were studied. Slides were fixed in 95% ethyl alcohol and stained with Pap and Hematoxylin & Eosin stains. Slides were reported according to The 2001 Bethesda System, by two pathologists. RESULTS: Out of 221 patients studied, 179 showed inflammatory smear, three cases of atrophic smear, 21 cases with epithelial abnormalities and 18 cases were inadequate. Benign and inflammatory lesions were common in 21-30years and epithelial abnormalities were common in 41-50 years of age group.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon 9-35-11-ijprbs-187.26.pdf
  • 5
379-389
  • English

REFERENCES

References: 

1. National Cancer Registry Program. Annual Report IC.New Delhi; 1990-1996
2. Papanicolaou GN and Traut HF: The diagnostic value of vaginal smears in carcinoma of the uterus. Am J Obstet
Gynecol. 1941; 42:193-205
3. Koss LG: Epidermoid carcinoma of the uterine cervix and related precancerous lesions. Part 1: Natural history, definitions and experimental studies. In diagnostic Cytology and its Histopathologic Bases, 4th
edition. Vol.1. J.B.Lippincott Company:
Philadelphia, PA, 1992: 371-423
4. Sherman ME: Cytopathology. In: Kumaran RJ (ed). Blaustein's Pathology of the Female Genital Tract, 4th edition.Springer-Verlag: USA, 1994: 1097¬1130
5. Koss LG: The Papanicolaou test for cervical cancer detection 'A tripht and a
tragedy. Acta Cytol. 1990;29(7):1193-1197
Available Online At www.ijprbs.com
Research Article
Tirumalasetti Neelima, IJPRBS, 2012; Volume 1(5): 379-389
ISSN: 2277-8713
IJPRBS
6. The 2001 Bethesda system;Terminology for reporting results of cervical cytology.
JMA 287, 2114, 2002
7. Mandakini M Patel, Amrish N Pandya and Jigna Modi: Cervical pap smear study and its utility in cancer screening, to specify the strategy for cervical cancer control. National Journal of Community Medicine
2011; 2(1): 50.
8. Herrero R: Epidemiology of cervical cancer. J Natl Cancer InstMonogr 1996; 21: 1-6. 11. Eddy DM. Screening for cervical cancer. Ann Intern Med 1990; 113: 214-26.
9. Van der Graaf Y, Klinkhamer PJ and Vooijs GP: Effect of population screening for cancer of the uterine cervix in Nijmegen,
The Netherlands. Prev Med 1986; 15: 582¬90
10. The World Health Report, 1995. Bridging the gaps. Geneva: World Health Organization; 1995
11. Alliance for cervical cancer prevention (ACCP): Planning and implementing cervical cancer prevention and control programs: A manual for managers. Seattle: ACCP; 2004
12. ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynaecologists; 2009.
13. Cheryl L R, Clair W M and Kevin R: Prevention of cervical cancer. Critical review in Oncology /Hematology; 2000: 33: 169¬185.
14. Sherwani RK, Khan T, Akhtar K, Zeba A, Siddiqui FA, Rahman K and AfsanN: Conventional Pap Smear and Liquid Based Cytology for Cervical Cancer Screening - A Comparative Study; Journal of Cytology
2007; 24 (4) : 167-172
15. Kenneth DH and Yao S Fu: Cervical and vaginal cancer, Novak's Textbook of Obstetrics and Gynecology, 13th ed. Baltimore: WB Saunders Co; 2002.p.471-93.
16. Robert ME and Fu YS: Squamous cell carcinoma of the uterine cervix - a review with emphasis on prognostic factors. Semin
Diagn Pathol 1990; 7: 173-89.
17. Ranabhat SK, Shrestha R and Tiwari M: Analysis of abnormal epithelial lesions incervical Pap smears in Mid-Western Nepal: Journal of Pathology of Nepal (2011) Vol. 1, 30-33
Available Online At www.ijprbs.com
Research Article
Tirumalasetti Neelima, IJPRBS, 2012; Volume 1(5): 379-389
ISSN: 2277-8713
IJPRBS
18. Amphan Chalermchockcharoenkit, Chenchit Chayachinda, Manopchai Thamkhantho and Chulaluk Komoltri: Prevalence and cumulative incidence of abnormal cervical cytology among HIV-infected Thai women: a 5.5-year retrospective cohort study; BMC Infectious Diseases 2011; 11: 8.
19. Bhojani KR and Garg R:Cytopathological study of cervical smears and corelation of findings with risk factors; Int J Biol Med Res.
2011; 2(3): 757-761.
20. Sania Tanveer Khattak, Imran-ud-din
Khattak
, Tabassum Naheed and Shehnaz AkhtarTanveer Jamal: Detection of abnormal cervical cytology by pap smears; Gomal Journal of Medical Sciences July-Dec 2006:4 (2).
21. Rotkin: Epidermiology on cancer of the cervix. Sexual characteristics of cervical cancer population. Am J Public Health 1973;
57: 815-29.
22. Rejendra A Kalkar and Yogesh Kulkarini: Screening for cervical cancer: an overview. Obstet Gynecol India vol. 56 no. 2: March /
April 2006.
23. Amne E. Radar and Peter G. Rose: Atypical Squamous cells of undetermined significance in women over 55. Actacytologica; vol. 43, no. 3: 1999: 357-61.
24. Izabela T. Burja and Sophie K. Thompson: Atypical glandular cells of undetermined significance on cervical smears. Acta cytological. 1999; 43 (3): 357¬56.
25. Richard RM. Natural history of cervical
intraepithelia
l neoplasia. Clin Obstet Gynaecol 1968; 10: 748-50.
26. Mishra S, Srivastava S, Singh U and Srivastava AN: Risk factors and strategies for control of carcinoma cervix in India: Hospital based cytological screening experience of 35 years. Indian J
Cancer2009; 46: 155-9.

Thank you for copying data from http://www.arastirmax.com