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FORMULATION AND EVALUATION OF BILAYER MATRIX TABLET OF ACARBOSE AND METFORMIN HYDROCHLORIDE

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Abstract (2. Language): 
The aim of present study was to design the concept of bilayer matrix tablets containing Acarbose as immediate release component using sodium starch glycolate and cross carmillose sodium as super disintegrates and Metformin hydrochloride (HCl) for sustained release by using hydroxyl propyl methyl cellulose (HPMC K 4M), (HPMC K 100) and sodium carboxyl methyl cellulose (SCMC) as the matrix forming polymer and PVPK-30 as binder. Matrix tablet are the type of controlled drug delivery systems, which release the drug in continuous manner. These release the drug by both dissolution controlled as well as diffusion controlled mechanisms the half life of metformin HCl is 6.2 hrs, so an attempt was made in the direction of preparation and optimization of a combination of sustained release and immediate release in a single tablet. Tablets were prepared by wet granulation and direct compression method. Tablets were evaluated for post compression parameters. The tablets were evaluated for physico-chemical property. All the values were found to be satisfactory. Invitro release studies were carried as per USP in water and phosphate buffer of pH 6.8 using the apparatus I. The final preparation showed release of drug up to 96.75 in 8 hours. FTIR studies revealed that there is no interaction between the drug and other excipients used in the study.
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123-139

REFERENCES

References: 

1. Gilbert S Banker and Neil R: Anderson in Leon Lachman, Herbert A. Liebermann, the theory and practice of industrial pharmacy third edition, 1987: a) 293-294 b) 330-331 c) 430-431.
2. Abraham MA and Shirwaikar A: Formulation of multilayered sustain release tablets using insoluble matrix system, Indian Journal Pharmaceutical Science 1997: 312-315.
3. William C.Gunsel and Robert, compression coated and layer tablet, 1987, Libermann, the the theory and practice of industrial pharmacy third edition, 1987:
1274.
4. Charles Slchiou and Joseph R: Robinson, Remington's pharmaceutical science, 17th edition, page no. 1644-1653.
5. Harkishan Singh and Kapoor VK: Medicinal and Pharmaceutical Chemistry, 2nd edition-2005, reprint 2007: 377.
6. KD Tripathi: Essentials of Medicinal pharmacoloy; 5th edition: 235-245.
7. Raja Ponnambalam Pavithra VS: Review article of Diabetes Mellitus in the Asian Journal of diabetes; 2007: 1721.
8. PJ Pentikainen, PJ Neuvonen and A Penttila: Pharmacokinetics of metformin after intravenous and oral administration to man, Eur. J. Clin. Pharmacol. 1979; 16: 195¬202.
9. GT Tucker, C Casey, PJ Phillips, H Connor, JD Ward and HF Woods: Metformin kinetics in healthy subjects and in patients with diabetes mellitus, Br. J. Clin. Pharmacol. 1981; 12: 235-246.
10. N Vidon, S Chaussade, M Noel, C Franchisseur, B Huchet and JJ Bernier: Metformin in the digestive tract, Diabetes. Res. Clin. Pract. 1988; 4: 223-229.
11. LS Hermann and A Melander: Biguanides: basic aspects and clinical use, in: K.G.M.M. Alberti, R.A. De Fronzo, H. Keen (Eds.), International Textbook of Diabetes Mellitus, Wiley, New York, 1992:
772-795.
12. P Karttunen, M Uusitupa and U Lamminsivu: The pharmacokinetics of
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Research Article
Jyotsna Godbole, IJPRBS, 2012; Volume 1(6): 123-139
ISSN: 2277-8713
IJPRBS
metformin: a comparison of the properties of a rapid-release and a sustained-release preparation, Int. J. Clin. Pharmacol. Ther. Toxicol. 1983; 21: 31-36.
13. G Gusler, J Gorsline, G Levy, SZ Zhang, IE Weston, D Naret and B Berner: Pharmacokinetics of metformin gastric-retentive tablets in healthy volunteers, J. Clin. Pharmacol. 2001; 41: 655-661.
14. PH Marathe, Y Wen, J Norton, DS
Greene, TF Barbhaiya and IR Wilding: Effect of altered gastric emptying and gastrointestinal motility on metformin absorption, Br. J. Clin. Pharmacol. 2000; 50:
325-332.
15. RW Korsmeyer, R Gurny, E Doelker, P Buri and NA Peppas: Mechanisms of solute release from porous hydrophilic polymers,
Int. J. Pharm. 1983; 15: 25-35.

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