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FORMULATION, DEVELOPMENT AND OPTIMIZATION OF ORODISPERSIBLE TABLETS OF CETIRIZINE HYDROCHLORIDE

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Aim: To Formulate, Develop and Optimize Orodispersible Tablets (ODTs) of Cetirizine Hydrochloride. Methodology: Orodispersible Tablets were prepared by direct compression method using different superdisintegrants i.e. Croscarmellose, Crospovidone and Sodium Starch Glycolate. A 32 full factorial design was applied to systematically optimize the drug disintegration time. The concentration of Crospovidone (X1) and concentration of Croscarmellose(X2) were selected as independent variables. The Disintegration time (Y1) and Wetting time (Y2) were selected as dependent variables. The prepared tablets were evaluated for hardness, friability, Disintegration time, Wetting time and in vitro drug release. DSC studies were conducted for drug, and drug excipient mixture for interactions if any. Optimized batch was subjected to short term stability study. Results: Cetirizine HCl ODTs prepared were found to be of good quality fulfilling all the necessities for tablets. The results indicated that concentration of Crospovidone (X1) and concentration of Croscarmellose(X2) significantly affected the Disintegration time (Y1) and Wetting time (Y2).Drug Disintegration & Wetting time were affected by concentration of Crospovidone and concentration Croscarmellose. Disintegration time & Wetting time decreased as the concentration of Croscarmellose & Crospovidone increased. Regression analysis and numerical optimization were performed to identify the best formulation. Formulation F10 prepared with Croscarmellose (3.00) &Crospovidone (3.92) was found to be the best formulation with disintegration time 40.68sec & wetting time 33.66sec. Optimized formulation was found to be stable under accelerated stability studies. Conclusion: Orodispersible tablets of Cetirizine HCl were successfully formulated by direct compression technique with improved patient compliance & immediate onset of action.
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  • 6
218-238
  • English

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Available Online At www.ijprbs.com
Research Article ISSN: 2277-8713
Nitu Changoiwala, IJPRBS, 2012; Volume 1(6): 218-238 IJPRBS
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Available Online

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