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HEALTH BENEFITS OF POLYPHENOLS AND PREVENTION OF DISEASES IN HUMANS

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Abstract (2. Language): 
Increased consumption of fruits and vegetables is associated with a lower risk of chronic disease such as cardiovascular disease, some forms of cancer, and neurodegeneration. Pro-oxidant-induced oxidative stress contributes to the pathogenesis of numerous chronic diseases and, as such, dietary antioxidants can quench and/or retard such processes. Dietary polyphenols, i.e., phenolic acids and flavonoids, are a primary source of antioxidants for humans and are derived from plants including fruits, vegetables, spices, and herbs. Based on compelling evidence regarding the health effects of polyphenol-rich foods, new dietary supplements and polyphenol-rich foods are being developed for public use. Consumption of such products can increase dietary polyphenol intake and subsequently plasma concentrations beyond expected levels associated with dietary consumption and potentially confer additional health benefits. Furthermore, bioavailability can be modified to further increase absorption and ultimately plasma concentrations of polyphenols. However, the upper limit for plasma concentrations of polyphenols before the elaboration of adverse effects is unknown for many polyphenols. Moreover, a considerable amount of evidence is accumulating which supports the hypothesis that high-dose polyphenols can mechanistically cause adverse effects through pro-oxidative action. Thus, polyphenol-rich dietary supplements can potentially confer additional benefits but high-doses may elicit toxicity thereby establishing a double-edge sword in supplement use
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REFERENCES

References: 

1. Adlercreutz CH, Goldin BR and Gorbach SL: Soybean phytoestrogen intake and cancer risk. J Nutr, 125, 757-70. Adlercreutz H, Markkanen H, Watanabe S 1993). Plasma concentration of phyto-oestrogen in Japanese men. Lancet. 2003; 342: 1209-10.
2. Agrawal BB, Bhardwaj A and Agrawal RS: Role of resveratrol in prevention and therapy of cancer: Preclinical and clinical studies. Anticancer Res. 2004; 24: 2783¬840.
3. Alhasan S, Pietrasczkiwicz-Alonso MD, Ensley J and Sarkar FH: Genistein induced cell cycle arrest and apoptosis in a head and neck squamous cell carcinoma cell line.
Nutr Cancer. 1999; 34: 12-9.
4. Andriambeloson E, Kleschyov AL and Muller B: Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat arota. Br
J Pharmacol. 1997; 20: 1053-8.
5. Azmi AS, Bhat SH, Hanif S and Hadi SM: (2006). Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: Implication for a putative
ISSN: 2277-8713
İ9 IJPRBS
mechanism for anticancer properties. FEBS
Lett. 2006; 580: 533-8.
6. Bagli E, Stefaniotou M and Morbidelli L: Luteolin inhibits vascular endothelial growth factor induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Cancer Res. 2004; 64: 7936-46.
7. Bastianetto S, Yao ZX, Papadopoulos V and Quirion R: Neuroprotective effects of green and black teas and their catechin gallate esters against betaamyloid- induced toxicity. Eur J Neurosci. 2006; 23: 55-64.
8. Batista O, Doarte A, Nascimento J and Simones MF: Structure and antimicrobial activity of diterpenes from the roots of Plectranthus hereroensis. J Nat Prod. 1994; 57: 858-86.
9. Bauer V and Bauer F: Reactive oxygen species as mediators of tissue protection and injury. Gen Physiol Biophys. 1999; 18:
7- 14.
10. Belaia OL, Fomina IG, Baider LM, Kuropteva ZV and Tiukavkina NA: The influence of the bioflavonoid dicvertin on the antioxidative system ceruloplasmin-
Available Online At www.ijprbs.com
Review Article
D Jalaja Kumari, IJPRBS,
2012;
Volume 1(6): 166-189
ISSN: 2277-8713
IJPRBS
transferrin and lipid peroxidation in patients suffering from stable coronary heart disease with dyslipidemia. Clin Med. 2006; 84: 46¬50.
11. Beretz A, Anton R and Stoclet JC: Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase. Experimentia. 1977; 34: 1045-55.
12. Borris RP: Natural products research: perspectives from a major pharmaceutical company. J Ethnopharmacol. 1996; 51: 29¬38.
13. Bors W, Heller W and Michael M:
Flavonoids as antioxidants: determination of radical scavenging efficiencies. Edited by CA Rice, E Vans and L Packer, Marcel Dekker, New York. 1998.
14. Bryan SE: Metal ions in biological systems. Marcel Dekker, New York. 1979.
15. Casagrande F and Darbon JM: p21CIP1 is dispensable for the G2 arrest caused by genistein in human melanoma cells. Exp Cell
Res. 2000; 258: 101-8.
16. Chung SY, Sung MK and Kim NH:
Inhibition of Pglycoprotein by natural
products in human breast cancer cells. Arch
Pharm Res. 2005; 28: 823-8.
17. Cowan MM: Plant products as antimicrobial agents. Clin Microbial Rev.
1999; 12: 564-82.
18. Criqui MH and Ringel BL: Does diet or alcohol explain the French paradox? Lancet.
1994; 344: 1719-23.
19. Critchfield JW, Butsera ST and Folks TM: Inhibition of HIV activation in latently infected cells by flavonoids compounds. AIDS Res Hum Retroviruses. 1996; 12: 39¬46.
20. Critchfield JW, Coligan JE, Folks TM and
Butera ST: Casein kinase II is a selective target of HIV-1 transcriptional inhibitors. Proc Natl Acad Sci USA. 1997; 94: 6110-5.
21. Dai Q, Borenstein AR, Wu Y, Jackson JC and Larson EB: Fruit and vegetable juices and Alzheimer's disease: the Kame project.
Am J Med. 2006; 119: 751-9.
22. Davis JN, Kucuk O and Sarkar FH: Genistein inhibits NFkappa B activation in prostate cancer cells. Nutr Cancer. 1996;
35: 167-74.
Available Online At www.ijprbs.com
Review Article
D Jalaja Kumari, IJPRBS,
2012;
Volume 1(6): 166-189
23. De Clereq: Natural products for chemotherapy of human immunodeficiency virus (HIV) infection. Med Res Rep. 2000;
20: 323-49.
24. Desrosiers RC: Prospects for an AIDS vaccine. Nature Med. 2004; 10: 221-3.
25. Dewick PM: The biosynthesis of shikimate metabolites. Nat Prod Rep. 1995;
12: 579-607.
26. Dixon RA, Dey PM and Lamb CJ: Phytoalexins: enzymology and molecular biology. Adv Enzymol. 1983; 55: 1-69.
27. Ebadi M and Swanson S: The status of zinc, copper and metallothionein in cancer patients. Prog Clin Biol Res. 1988; 259: 161¬75.
28. Falchi M, Bertelli A and Le Scalzo R: Comparison of cardioprotective abilities between the flesh and skin of grapes. J
Agric Food Chem. 2006; 54: 6613-22.
29. Fauci AS: Host factors and the pathogenesis of HIV induced disease.
Nature. 1996; 384: 529-34.
30. Feng Q, Dongzhi W, Qiang Z and Shengli Y: Modulation of P-glycoprotein function and reversal of multidrug resistance by (-)-
ISSN: 2277-8713 IJPRBS
epigallocatechin gallate in human cancer cells. Biomed Pharmacother. 2005; 59: 64-9.
31. Figtree GA, Griffiths H and Lu YQ: Plant-
derived estrogens relax coronary arteries in vitro by a calcium antagonistic mechanism.
J Am Coll Cardiol. 2000; 35: 1977-85.
32. Firuzi: Hypochlorite scavenging activity of flavonoids. J Pharma Pharmacol. 2004;
56: 801-7.
33. Fung MC: Effect of biochanin A on the growth and differentiation of myeloid
leukemia. Life Sci. 1997; 61: 105-15.
34. Gali HV Perchellet EM, Klish DS, Johnson JM and Perchellet JP : Hydrolyzable tannins: potent inhibitors of hydroperoxide production and tumor promotion in mouse skin treated with 12-0-tetradecanoyl phorbol-13-acetate in vivo. Int J Cancer.
1992; 51: 425-32.
35. Geissman TA: Flavonoid compounds, tannins and related compounds, In: Florkin, M. and Stotz, E.H., (Ed), Pyrrole Pigments, Isoprenoid Compounds and Phenolic Plant Constituents. Elsevier, New York. 1963; pp
265.
Available Online At www.ijprbs.com
Review Article
D Jalaja Kumari, IJPRBS,
2012;
Volume 1(6): 166-189
ISSN: 2277-8713
IJPRBS
36. German JB and Walzem R: The health benefits of wine. Annu Rev Nutr. 2000; 20: 561-93.
37. Ghadge GD, Lee JP and Bindokas VP: Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis, molecular mechanisms of neuronal death and protection. J Neuro Sci. 1997; 17: 8756¬66.
38. Hadi SM, Asad SF, Singh S and Ahmad A: Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds. IUBMB
Life. 2000; 50: 1-5.
39. Hadi SM, Asfar AS and Bhat SH:
Oxidative breakage of cellular DNA by plant polyphenols: A putative mechanism for anticancer properties. Semin Cancer Biol.
2007; 17: 370-7.
40. Hillman GG, Forman JD and Kucuk O: Genistein potentiates the radiation effect on prostate carcinoma cells. Clin Cancer
Res. 2001; 7: 382-90.
41. Hillman GG, Wang Y and Kucuk O: Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer
orthotopic model. Mol Cancer Ther. 2004;
3: 1271- 9
42. Hsu JT, Hung HC, Chen CJ and Ying C:
Effect of dietary phytoestrogen biochanin A on cell growth in the mammary carcinoma
cell line MCF-7. J Nut BioChem. 1999; 10: 510-7.
43. Ireson CR, Orr S and Jones DJL : Characterization of metabolites of the chemopreventive agent curcumin in humans and rat hepatocytes and in rat plasma and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res. 2001; 61: 1058¬64.
44. Joseph JA, Denisova NA and Arendash G: Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci.
2003; 6: 153-62.
45. Joseph JA, Shukitt-Hale B and Denisova N: Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci. 1999; 19:
8114-21.
Available Online At www.ijprbs.com
Review Article
D Jalaja Kumari, IJPRBS,
2012;
Volume 1(6): 166-189
ISSN: 2277-8713
IJPRBS
46. Joyce CL, Mack SR, Anderson RA and Zaneveld LJD: Effect of hyaluronidase, beta-glucuronidase and beta-N-acetyl glycosamminidase inhibitors on sperm penetration of the mouse oocytes. Biol
Reprod. 1986; 35: 336-46.
47. Kawai K, Tsuno NH and Kitayama J: Epigallocatechin gallate the main component of tea polyphenol binds to CD4 and interferes with gp120 binding. J Allergy Clin Immunol. 2003; 112: 851-3.
48. Kazmi MH, Malik A, Hameed S, Akhtar N and Ali SN: An anthraquinone derivative from Cassia italica. Phytochem. 1994; 36:
761-3.
49. Kim H, Park BS and Lee KG: Effects of
naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. J Agric Food Chem. 205; 53: 8537¬41.
50. Koh SH, Lee SM and Kim HY: The effect of epigallocatechin gallate on expressing diseases progression of ALS model mice.
Neuro Sci Lett. 2006; 375: 103-7.
51. Krishnaveni KS and Rao JVS: A new isoflavone glucoside from Pterocarpus
santalinus. Asian Nat Prod Res. 2000 ; 2 : 219.
52. Kuiper GGM, Lemmen JG, Carlsson B : Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor a. Endocrinology. 1998; 139: 4252-63.
53. Kyle E, Neckers L, Takimoto C, Curt G and Bergan R: Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol Pharmacol. 1997; 5: 193-200.
54. Lambert DJ, Hong J, Yang G, Lias J and Yand SC: Inhibition of carcinogenesis by polyphenols evidence from laboratory
investigations. AJCN. 2005; 81: 2845-91
55. Li CJ, Dezube BJ, Biswas DK, Ahlers CM and Pardee AB: Inhibition of HIV-1 Transcription. Trends Microbiol. 1994; 5:
164- 9.
56. Li HL, Huang Y and Zhang CN:
Epigallocathechin-3 gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways. Free Radic
Biol Med. 2006; 40: 1756-75.
Available Online At www.ijprbs.com
Review Article
D
Jalaja Kumari, IJPRBS, 2012; Volume 1(6):
57. Lyn Cook BP, Stottman HL, Yan Y and Hamous GJ: The effects of phytoestrogen on human pancreatic tumor cells in vitro.
Cancer Lett. 1999; 142: 111-119.
58. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC: Multiple biological activities of curcumin: A short review. Life Sci. 2006; 78:
2081-87.
59. Manjunatha BK: Antibacterial activity of Pterocarpus santalinus. Ind J Pharm Sci.
2006; 68: 115-6.
60. Mason TL and Wasserman BP. Inactivation of red beet bglucan synthetase by native and oxidized phenolic compounds. Phytochem. 1987; 26: 2197.
61. Middleson E: The flavonoids. Trends Pharmacol Sci. 1984; 5: 335-8.
62. Mills PK, Beeson WL, Philips RL and Fraser GE: Cohurt study of diet, lifestyle and prostate cancer in Adventist men. Cancer.
1989; 64: 598-604
63. Morley KL, Ferguson PJ and Koropatrick: Tangeretin and nobiletin induce G1 cell arrest but not apoptosis in human breast and colon cancer cells. Cancer Lett. 2007 ;
251 : 168-178.
ISSN: 2277-8713
9 IJPRBS
64. Morris MC, Evans DA and Bienias JL : Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA. 2002; 287: 3230-7.
65. Mukhopadhyay A, Basu N, Ghatak N and Gujral PK: Antiinflammatory and irritant activities of curcumin analogues in rats. Agents Actions. 1982; 12, 508-15.
66. Nair MP, Kandaswami C, Mahajan S: Grape seed extract proanthocyanidins down regulate HIV-1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells.
Biol Res. 2002; 35: 421-1.
67. Nakahara K, Kawabata S and Ono H: Inhibitory effects of oolong tea polyphenols on glucosyltransferases of mutans streptococci. Appl Environ Microbiol. 1993;
59 : 968-73.
68. Narayanan BA : Chemopreventive agents alters global gene expression pattern: Predicting their mode of action and targets. Curr Cancer Drug Targets. 2006; 6:
711-27.
69. Papavassiliou AG: Transcription factors: Structure, function and implication in
Available Online At www.ijprbs.com
Review Article
D Jalaja Kumari, IJPRBS, 2012; Volume 1(6):
malignant growth. Anticancer Res. 1995;
15: 891-4.
70. Perry
G
, Sayre LM and Atwood CS: The role of iron and copper in the etiology of neurodegenerative disorders: therapeutic implications. CNS Drugs. 2002; 16: 339-52.
71. Philips M, Sabas M and Greenberg J: Increased pentane and carbon disulfide in the breath of patients with schizophrenia. J
Clin Pathol. 1993; 46: 861-864.
72. Ramassamy C: Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur J Pharmacol.
2006; 545: 51-64
73. Rike L, Samedi VG, Medrans TA and Baker HV: Mechanism of the growth inhibitory effect of the isoflavonoid biochanin A on LNCaP cells and xenograft.
The Prostate. 2002; 52: 201-12.
74. Rowland
I
, Faughnan M L and Hoey K: Bioavailability of phyto-oestrogens. Br J
Nutr. 2003; 89: 838-52.
75. Scalbert A and Williamson G: Dietary intake and bioavailability of polyphenols. J
Nutr. 2000; 130: 2073-85.
ISSN: 2277-8713
9 IJPRBS
76. Scarlatti F, Sala G and Rici C: Resveratrol sensitization of DU145 prostate cancer cells to ionizing radiation is associated to ceramide increase. Cancer Lett. 2007; 253:
124-30.
77. Schroeter H, Spencer JP, Evans CR and William RT: Flavonoids protect neuron from toxicologic low-density lipoprotein induced apoptosis. Biochem J. 2006; 388: 547-57.
78. Schultes RE: The kingdom of plants, In: WAR Thomas (Ed), Medicines from the Earth. Mc Graw Hill Book Co, New York 1978: 208.
79. Shang YZ, Qin BW, Cheng JJ and Miao H: Prevention of oxidative injury by flavonoids from stems and leaves of Scutellaria baicalensis georgi in PC12 cells. Phytother
Res. 2006; 20: 53-7.
80. Shen J, White M, Husband AJ, Hambly
BD and Bao S: Phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. Eur J Pharmacol. 2006; 548: 123-8.
81. Shuzhong Z, Xinning Y, Robert AC and Marilyn EM: Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated
Available Online At www.ijprbs.com
Review Article
D Jalaja Kumari, IJPRBS,
2012;
Volume 1(6): 166-189
ISSN: 2277-8713
IJPRBS
inhibition of breast cancer resistance protein. Biochem Pharmacol. 2005; 70: 627¬39.
82. Singh
S
and Aggarwal
BB
: Activation of transcription factor NF-kB is suppressed by curcumin (diferulolylmethane). J Biol Chem.
1995; 270: 24995-25000.
83. Stern
SL
, Hagerman AE, Steinberg PD and Mason PK: Phlorotannin-protein interactions. J Chem Ecol. 1996 ; 22 : 1887¬90.
84. Sugiyama Y, Kawakashi S and Osawa T: Involvement of the beta-diketone moiety in the antioxidant mechanism of tetrahydrocurcumin. Biochem Pharmacol.
1996; 52: 519-25.
85. Szewczuk LM, Forti L, Stivala LA, Penning TM: Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004; 279: 22727-37.
86. Toda MS, Okubo R, Ohnishi OR, Shimamura T: Antibacterial and bactericidal activities of Japanese green tea. Jpn J
Bacteriol. 1989; 45: 561-6.
87. Tsuchiya H, Sato M and Miyazaki T: Comparative study on the antibacterial activity of phytochemical flavanones against methicillin resistant Staphylococcus aureus. J Ethnopharmacol. 1996; 50: 27-34
88. Tsvetkov P, Asher G and Reiss V: Inhibition of NAD [P] H: Quinone oxido reductase 1 activity and induction of P53 degradation by natural phenolic compound curcumin. Proc Natl Acad Sci USA. 2005; 102: 5535-40.
89. Ullah MF: Cancer therapeutics: Emerging targets and trends. Curr Cancer
Ther Rev. 2008; 4: 50-6.
90. Ullah MF: Cancer multidrug resistance (MDR): A major impediment to effective chemotherapy. Asian Pac J Chem Prev.
2008; 9: 1-6
91. Ulrich A, Schlesinger J: Signal transduction by receptors with tyrosine
kinase activity. Cell. 1990; 61: 203-212.
92. Verma R, Gupta RB and Singh K: Distribution of CCR5 Delta 32, CCR2-641
and SDF1-3A and plasma levels of SDF-1 in HIV-1 seronegative North Indians. J Clin
Virol. 2007; 38: 198-203.
Available Online At www.ijprbs.com
Review Article
D Jalaja Kumari, IJPRBS, 2012; Volume 1(6): 166-189
ISSN: 2277-8713
IJPRBS
93. Vijaya K, Ananthan S and Nalini R: Antibacterial effect of theaflavin, polyphenol (Camellia sinensis) and Euphorbia hirta on Shigella spp. - a cell culture study. J Ethnopharmacol. 1995; 49:
115-8.
94. Wahl H, Tan L, Griffith K, Choi M and Liu
RJ: Curcumin enhances Apo2L/TRAIL-induced apoptosis in chemoresistant ovarian cancer cells. Gynecol Oncol. 2007;
105: 104-12.
95. Walker HA, Dean TS and Sanders TA: The phytoestrogen genistein produces acute nitric oxide dependent dilation of human forearm vasculature with similar potency to 17^-estradiol. Circulation. 2001;
103: 258-62.
96. Wallerath T, Deckert G and Ternes T: Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 2002; 106: 1652-8.
97. Wang J, Ho L and Zhao Z: Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease. FASEB
J. 2006; 20: 2313- 20
98. Wenzel E and Somoza V: Metabolism and bioavailability of trans-resveratrol. Mol
Nutr Food Res. 2005; 49: 472-81.
99. Wollenweber E: Occurrence of flavonoid aglycones in medicinal plants. Prog Clin Biol
Res. 1988; 280: 45-55.
100. Wu Baer F, Lane WS, Gaynor RB: The
cellular factor TRP-185 regulates RNA polymerase binding to HIV-1 TAR RNA. EMBO J. 1995; 14: 5995-6009.
101. Xia Y, Jin L, Zhang B : The potentiation of curcumin on insulin-like growth factor-1 action in MCF-7 human breast carcinoma
cells. Life Sci. 2007; 80: 2161-9
102. Xu Z, Chen S, Li X, Luo G, Li L and Le W: Neuroprotective effects of (-)-epigallocateclun-3-gallate in a transgenic mouse model of amyotrophic lateral sclerosis. Neurochem Res. 2006; 31: 1263-9.
103. Yacoub A, Park JS, Qiao L, Dent P and Hegan MP: MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in MEK K dependent fashion. Int J Radiat Biol. 2001;
77: 1067-78.
Available Online At www.ijprbs.com
Review Article
D Jalaja Kumari, IJPRBS,
2012;
Volume 1(6): 166-189
ISSN: 2277-8713
IJPRBS
104.
Yoshid
a D, Ikada Y and Nakayama S: Quantitative analysis of copper, zinc and copper/zinc ratio in selective human brain tumors. J Neuro Oncol. 1993; 16: 109-15.
105. Zhang
GH
, Wang Q and Chen JJ: The anti-HIV I effect of scutellarin. Biochem Biophys Res Commun. 2005; 334: 812- 816.

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