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DEVELOPMENT OF NEW ANALYTICAL TECHNIQUES FOR THE QUALITY OF ANTI-AIDS DRUGS

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
A simple, accurate, sensitive and rugged analytical method has been developed and validated for related estimation of Emticitabine in capsule dosage form. separation was achieved on a Hypersil BDS C18 (100 mm × 4.6 mm i.d., particle size 5 μm, maintained at ambient temperature) by a mobile phase consisted of buffer, acetonitrile and Methanol (85:10:5 v/v) with apparent pH of 2.2 and a flow rate of 1.5 ml/min. The detection wavelength was set at 280 nm. The different analytical parameters such as linearity, accuracy, precision, robustness were determined according to the International Conference on Harmonization (ICH) Q2B guidelines. The method was linear (r = 0.9990) concentration range of 50 - 149 μg/ml. The proposed method is highly sensitive, precise, accurate and easy to perform hence was successfully applied for the quantification bulk and capsule dosage form.
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  • 1
63-77
  • English

REFERENCES

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