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The Aim of this study was to investigate the hepatoprotective effect of aqueo extract of Aloe vera against carbontetrachloride induced hepatotoxicity in rats. 36 Albino wistar rats (150 normal saline (2ml/100g orally), II group received 1 ml/kg of carbontetrachloride intraperitoneally (i.p.), III group was given Liv.52 (2 ml/kg) orally for ten days followed by carbontetrachloride i.p. on 10 (2ml/100g/day) for 10, 20 & 30 days respectively followed by carbontetrachlorid on 10 rats were anaesthetized with ketamine (75 mg/kg) and diazepam (10 mg/kg). Blood was collected & then animals were sacrificed to take out the liver for histopat examination. The sera were used to estimate alanine aminotransferase, alkaline phosphatase & total billirubin and liver were subjected to histopathological examination. Alkaline phosphatase, alanine transaminase & total billirubin level in normal increased in carbon tetra chloride treated group. Aloe vera extract displayed significantly low values of alkaline phosphatase, alanine aminotransferase & billirubin in group III, IV It can be concluded that Aloe vera extract is a potent hepatoprotective agent.



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