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FORMULATION DESIGN AND EVALUATION OF SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM OF CIPROFLOXACIN

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
The objective of the present research work emulsifying drug delivery system (SMEDDS) of Ciprofloxacin drug, a poorly water soluble anti-microbial drug that exhibits low bioavailability. Solubility of ciprofloxacin in various oils, surfactants and co surfactants was determined. Phase diagram were constructed at different ratios of surfactants (tween 80, pluronic F127), co surfactant (ethanol) and oil (oleic acid) to determine microemulsion existence region to find out the optimized formulation. Pluronic F127 used as a sur solubilizing agent profile. There are different ratios of formulations were prepared, out of them three formulations (F3, F4 & F5) were selected as o/w microemulsion formulations and evaluated for in studies, percent drug content and stability studies to find out the optimized o/w microemulsion formulation. Drug content of F3 was more than F4 & F5 because of increased solubility of drug in excipients. F3 formulation is the optimized o/w microemulsion formulation than F4 & respect the results obtained by percent drug content, release and stability study profile. Shape morphology of F3 o/w microemulsion is approx 338.46nm to 554.70nm. Size distribution and zeta potential of F3 is 360nm and -7.64mv respectively. This indicates plateau of moderate stability & no agglomerates. All formulations (F3, F4 & F5) were shown good physical stability and slightly reduced chemical stability due to results found from % drug content studies. The deve highlight safety for use and potential applications of used components in the development of novel drug delivery system.
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  • 1
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  • English

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