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SYNTHESIS AND BIOLOGICAL ACTIVITY OF PYRROLE AND PYRROLIDINE COMPOUNDS FROM 4-CHLORO-2-HYDROXYBENZOIC ACID HYDRAZIDE

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Abstract (2. Language): 
4-chloro-2-hydroxy benzoic acid hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4- chloro-2-hydroxy benzoic acid arylidene hydrazides (2a-h) in good yields. Cyclocondensation of compounds (2a-h) with maleic anhydride and succinic anhydride yields respectively 1-(4-chloro-2-hydroxybenzamido)-5- oxo-2-aryl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3a-h) and 1-(4-chloro- 2-hydroxybenzamido)-5-oxo-2-arylpyrrolidine-3-carboxylic acid (4a-h). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.
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Available Online At www.ijprbs.com
Research Article
Sonal Mehta, IJPRBS, 2013; Volume 2(1): 382-394
ISSN: 2277-8713
IJPRBS
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