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CLINICAL STUDY OF THYROTROPIN AND PROLACTIN LEVELS IN WOMEN WITH PRIMARY INFERTILITY

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
INTRODUCTION: Infertility is defined as failure of couple to achieve pregnancy despite one year of regular unprotected sexual intercourse during reproductive age. Female factors contribute more towards infertility when compared to those of men. Hypothyroidism is the most common endocrine disorder affecting females. AIMS AND OBJECTIVES: To evaluate the impact of thyrotropin and prolactin levels on menstrual function and fertility of women with primary infertility. MATERIALS AND METHODS: The study was conducted on 240 subjects in reproductive age group (20¬40 years of age). Among the subjects, 160 were women with primary infertility and 80 were normal fertile women. Fasting venous samples on 3rd day of menstrual cycle were collected and estimation of thyrotropin and prolactin levels were done by using acculite (German) kits on semi chemiluminiscence instrument. RESULTS: The results were expressed as mean ± SD with a thyrotropin value of 2.16 ± 0.94 (in controls) and 28 ± 9.26 (in cases). Prolactin values were 12.58 ± 6.9 (in controls) and 52.9 ± 27.17 9(in cases). Both the thyrotropin and prolactin levels on comparison with cases and controls showed a significant pvalue of<0.001. CONCLUSIONS: Thyrotropin and prolactin levels showed significant difference when compared, between cases and controls which indicate that there is significant influence of hypothyroidism over serum prolactin levels which contributes to decrease in gonadotropins leading to primary infertility.
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  • 3
107-113
  • English

REFERENCES

References: 

1. N. Akhter, S.A. Hassan: Sub-clinical hypothyroidism and hyperprolactinemia in infertile women: Bangladesh perspective after universal salt iodination. The Internet Journal of Endocrinology. 2009 Volume 5 Number 1. DOI: 10.5580/8a.
2. Healy DL et al. (1994) Female infertility: causes and treatment. Lancet 343: 1539¬1544.
3. Doufas AG, Mastorakos G. The hypothalamicpituitary- thyroid axis and the female reproductive system. Ann N Y Acad Sci. 2000; 900: 65-76.
4. Poppe K, Velkeniers B, Glinoer D. Thyroid disease and female reproduction.
Clin Endocrinol (Oxf). 2007; 66(3): 309-21.
ISSN: 2277-8713
IJPRBS
5. Poppe K, Velkeniers B. Thyroid and infertility. Verh K Acad Geneeskd Belg 2002; 64: 389-99.
6. Raber W, Gessl A, Nowotny P, Vierhapper H. Hyperprolactinemia in hypothyroidism: clinical significance and impact of TSH normalization. Clin Endocrinol 2003; 58: 185-91.
7. Elahi S, Tasneem A, Nazir I, Nagra SA, Hyder SW. Thyroid dysfunction in infertile women. J Coll Physicians Surg Pak. 2007;
17(4):191-4.
8. Mishra R, Baveja R, Gupta V. Prolactin level in infertility with menstrual irregularities. J Obstet Gynecol India. 2002;
52: 40-3.
9. Olivar AC, Chaffkin LM, Kates RJ, Allan
TR, Beller P, Graham NJ. Is it necessary to obtain serum levels of thyroid stimulating hormone and prolactin in asymptomatic women with infertility? Conn Med 2003; 67:
393-5.
10. Jones RL et al. (2004) Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and
Available Online At www.ijprbs.com
Research Article
Sunitha Tirumalasetty, IJPRBS, 2013; Volume 2(3): 107-113
ISSN: 2277-8713 IJPRBS
menstruation. J Clin Endocrinol Metab 89:
6155-6167.
11. Honbo KS, Van Herle AJ, Kellett KA.
Serum prolactin levels in untreated primary hypothyroidism. Am J Med 1978; 64: 782-7.
12. Thomas R, Reid RL. Thyroid disease and reproductive dysfunction: a review. Obstet
Gynecol 1987; 70: 789-98.
13. Dajan CM, Saravanan P. Whose normal thyroid function is better- yours or mine? Lancet 2002; 360: 353-4.
14. Kumkum A, Jasmine K, Shweta G, Pal Ajeshwar N. Hyperprolactinema and its coorelation with hypothyroidism in infertile women. J Obstet Gynecol India. 2006; 56(1):
68-71.
15. Choudhury SD, Goswami A. Hyperprolactinemia and reproductive disorders-- a profile from north east. J Assoc Physicians India. 1995; 3(9): 617-8.

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