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DEVELOPMENT OF STABLE LATANOPROST OPHTHALMIC COMPOSITION USING NANOEMULSION APPROACH

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Latanoprost is water insoluble and is unstable against heat stress due to hydrolysis of the isopropyl ester in the latanoprost molecule. Therefore, the storage condition of latanoprost ophthalmic solution, Xalatan® brand, was in a cold temperature (2-8oC). We formulated a favorable ophthalmic nanoemulsion of latanoprost using poloxamer as emulsifier which showed good heat stability. The assays of the latanoprost ophthalmic nanoemulsions adjusted to pH 5.5, 6.5 and 7.5 were 100.8%, 100.6% and 99.4% after storage for 8 weeks at 60oC, respectively. The possibility of room temperature storage for the latanoprost ophthalmic nanoemulsion was demonstrated
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  • 4
274
279
  • English

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Available Online at www.ijprbs.com
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Kashyap Nagariya, IJPRBS, 2013; Volume 2(4): 274-279
ISSN: 2277-8713
IJPRBS
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