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ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC ACTIVITY OF ETHANOL EXTRACT OF MELASTOMA MALABATHRICUM L. LEAF IN ALLOXAN INDUCED DIABETIC RATS

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Abstract (2. Language): 
The ethanol extract of Melastoma malabathricum leaf (Family: Melastomataceae) was investigated for its antihyperglycemic and antihyperlipidaemic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of alloxan monohydrate (150mg/kg, i.p). The ethanol extract of Melastoma malabathricum at a dose of 150 and 300mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of Melastoma malabathricum leaf on blood glucose, serum insulin, urea, creatinine, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglycerides (TG), low density lipoprotein – cholesterol (LDL-C), very low density lipoprotein – cholesterol (VLDL-C), high density lipoprotein – cholesterol (HDL-C) and phospholipid (PL)] serum protein, albumin, globulin, serum enzymes [Serum Glutamate Pyruvate Transaminases (SGPT), Serum Glutamate Oxaloacetate Transaminases (SGOT), and Alkaline Phosphatase (ALP)] were measured in the diabetic rats. The ethanol extract of Melastoma malabathricum leaf elicited significant reductions of blood glucose (p<0.05), lipid parameters except HDL-C, serum enzymes and significantly increased HDL-C. The extracts also caused significant increase in serum insulin (p<0.05) in the diabetic rats. From the above results, it is concluded that ethanol extract of Melastoma malabathricum possesses significant antihyperglycemic and antihyperlipidaemic effects in alloxan induced diabetic rats.
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